Cardiovascular Diseases Clinical Trial
Official title:
The Vascular Effects of Nitrite on Coronary Flow Under Normoxia and Hypoxia
This study is a pharmacodynamic proof of concept study investigating the physiological effects of systemic infusion of nitrite on coronary blood flow using MRI.
This is a healthy volunteer, proof of concept study.
The participant will have blood taken and this will be analysed for baseline levels of
nitrate, nitrite and nitroso species. They will then have a baseline MRI to assess coronary
flow in normoxia. Next, hypoxia will be induced using 12% oxygen/88% nitrogen. The
participant will then have a baseline MRI to assess coronary flow in hypoxia (3 breath-hold
image captures).
After all baseline images have been captured, the investigators will commence an intravenous
nitrite sodium infusion, dose 70μmol, of 5 minute duration (14μmol /min-1). At the 5th
minute, the participant have a further MRI image to assess coronary flow with the
intervention in normoxia (3 breath-hold image captures).
A 10-minute washout will follow (with the half-life of nitrite being documented as 110
seconds). There will be optional repeat 3 breath-hold image captures at 5 minutes and at 10
minutes.
Next hypoxia will be induced using 12% oxygen/88% nitrogen again. The investigators will
commence a second intravenous nitrite sodium infusion, dose 70μmol, 5 minute duration (14μmol
/min-1). At the 5th minute, the participant will have a further MRI image to assess coronary
flow with the intervention in hypoxia (3 breath-hold image captures).
At the end of the study the participant will have blood taken and this will be analysed for
repeat levels of nitrate, nitrite and nitroso species.
All interventions will be performed by fully trained and competent medical staff.
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