Cardiovascular Diseases Clinical Trial
To determine the rate of progression of sub-clinical cardiovascular disease as measured in carotid intimal medial thickness over a period of 8 to 10 years.
BACKGROUND:
Strong associations exist between cardiovascular events and increased carotid artery wall
intima-media thickness (IMT) as measured non-invasively by carotid ultrasound. Carotid IMT
is accepted as a surrogate marker of sub-clinical cardiovascular disease.The study will
determine the rate of progression of sub-clinical cardiovascular disease (change in IMT)
over a period of 8 to 10 years.
DESIGN NARRATIVE:
The study will determine the rate of progression of sub-clinical cardiovascular disease
(change in intimal medial thickness {IMT}) over a period of 8 to 10 years. Imaging and IMT
measurements of approximately 2800 to 3000 members of the Framingham Offspring cohort having
had baseline IMT measurements at their 1995-98 clinic visit will be repeated in 2005-2007.
The principal aims of the project are to study the primary hypotheses that: 1. Interim
exposure to traditional cardiovascular risk factors measured over 50 years is positively
associated with the progression rate of carotid IMT. 2. Baseline carotid IMT and cumulative
exposure to cardiovascular risk factors 20 years before the baseline visit are a better
predictor of progression of sub-clinical disease after 8 to 10 years than the interim
exposure to risk factors. 3. Novel risk factors such as C-reactive protein and homocysteine
affect progression of carotid atherosclerosis more than traditional risk factors. This study
will add a phenotypic marker of site-specific change in sub-clinical cardiovascular disease
to the Framingham Study database. This complements ongoing research on the progression of
sub-clinical cardiovascular disease and its associations with family history of premature
cardiovascular events and genomic markers
;
Observational Model: Cohort, Time Perspective: Prospective
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