Cardiovascular Disease Clinical Trial
Official title:
Prospective Study for Evaluation of the Insulin Resistance, Lipid Metabolism and Sub Clinical Cardiovascular Disease in Women Who Initiate the Depot-medroxyprogesterone Acetate (DMPA) Contraceptive Method With in Follow-up for Two Years
Objective:
The purpose of this study is to determine the etiology of the weight increase in
Depot-medroxyprogesterone Acetate (DMPA) users.
Method:
Prospective study with 100 women, aged 18-40 years old and BMI < 30kg/m², paired with users
of a non hormonal method follow for two years. Will be included only women who never used
DMPA. There will be evaluated habit, blood pressure, anthropometric measure, distribution of
corporal fat, lipids profile and glycemia parameters every six months. Thirty women and
their control group will performed a euglycemic-hyperinsulinemic clamp to evaluate the
resistance of insulin, adiponectin,neuropeptide Y, apolipoprotein A/B and arterial
evaluation with ultrasound, intimal and media measure. Anova analysis for repeated samples.
The metabolic alterations should elucidate the etiology, and the beginning of the sub
clinical cardiovascular disease should be shown/discarded with the arterial evaluation.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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