Cardiac Disease Clinical Trial
Official title:
Parametric Mapping in Paediatric Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is increasingly an important tool for diagnosis and
management of cardiac diseases in children.
One of the uses of MRI is tissue characterisation, in which the signal characteristics of the
cardiac muscle (myocardium) can be determined with special techniques, known as parametric
mapping.
There is increasing evidence that parametric mapping may be able to identify regions of
scarring in the myocardium, or detection of oedema/inflammation in the setting. This in turn
can help predict disease course and add value to the management of patients.
There is also evidence that other structures that are visualised in parametric mapping aside
from the heart (e.g. liver and spleen) can also help improve diagnostic accuracy and guide
management.
Currently the majority of studies describing the use of parametric mapping is focused on
adults, with limited data on its use in children.
The parametric mapping values can also differ amongst different machines, so calibration with
normal subjects are also required.
Status | Recruiting |
Enrollment | 250 |
Est. completion date | December 1, 2022 |
Est. primary completion date | June 30, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A to 18 Years |
Eligibility |
Inclusion Criteria: - Healthy volunteers - Paediatric patients <=18 years of age with suspected or confirmed cardiac disease undergoing clinically indicated MRI Exclusion Criteria: - Unstable or uncooperative patients that cannot tolerate MRI - Patients with contraindications for MRI (e.g. patients with implanted devices that are not MRI compatible) |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Department of Radiology, Hong Kong Children's Hospital | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Hong Kong Children's Hospital |
Hong Kong,
Anderson LJ. Assessment of iron overload with T2* magnetic resonance imaging. Prog Cardiovasc Dis. 2011 Nov-Dec;54(3):287-94. doi: 10.1016/j.pcad.2011.07.004. Review. — View Citation
Kim PK, Hong YJ, Im DJ, Suh YJ, Park CH, Kim JY, Chang S, Lee HJ, Hur J, Kim YJ, Choi BW. Myocardial T1 and T2 Mapping: Techniques and Clinical Applications. Korean J Radiol. 2017 Jan-Feb;18(1):113-131. doi: 10.3348/kjr.2017.18.1.113. Epub 2017 Jan 5. Review. — View Citation
Messroghli DR, Moon JC, Ferreira VM, Grosse-Wortmann L, He T, Kellman P, Mascherbauer J, Nezafat R, Salerno M, Schelbert EB, Taylor AJ, Thompson R, Ugander M, van Heeswijk RB, Friedrich MG. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI). J Cardiovasc Magn Reson. 2017 Oct 9;19(1):75. doi: 10.1186/s12968-017-0389-8. Erratum in: J Cardiovasc Magn Reson. 2018 Feb 7;20(1):9. — View Citation
Riesenkampff E, Messroghli DR, Redington AN, Grosse-Wortmann L. Myocardial T1 mapping in pediatric and congenital heart disease. Circ Cardiovasc Imaging. 2015 Feb;8(2):e002504. doi: 10.1161/CIRCIMAGING.114.002504. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Parametric mapping values of normal subjects and patients | Parametric mapping values are generated upon completion of the MR sequence | through study completion, up to 2 years |
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