Post-Resuscitation Pneumothorax - Analysis of Incidence, Risk Factors and Outcome Relevance

Cardiac Arrest Clinical Trial

Official title:

Pneumothorax After Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - Analysis of Incidence, Risk Factors and Impact on Outcome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06182007
• Other study ID #: PostCPRptx
• Status: Completed
• Start date: February 2, 2020
• Est. completion date: December 31, 2022

Study information

• Verified date: December 2023
• Source: Medical University of Graz
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In this retrospective study, the investigators seek to investigate the incidence of pneumothorax following possible risk factors, and elucidate its association with outcomes.

Description:

This is a retrospective analysis of routine data, collected by a single Emergency Medical System (EMS). Adult patients (≥18 years) hospitalised after Out-of-Hospital Cardiac Arrest (OHCA) who received chest compressions and underwent chest imaging within 12 hours after hospital admission were included. Variables and outcomes ascertained are built up of the core elements of the latest version of the Utstein Resuscitation Registry Template for OHCA. This includes sex, age, aetiology of arrest, response times of the first emergency medical service team and emergency physician, witnessed cardiac arrest, bystander CPR/AED, arrest location, first monitored rhythm, defibrillation time, drugs given, reperfusion attempted and target temperature management. Additional variables studied were pre-existing health status represented by the Pre Emergency Status Assessment (PESA), history of lung disease, no-flow-time (time from collapse until initiation of CPR), use of a mechanical chest compression device and prehospital CPR duration. The primary outcome is incidence of pneumothorax, secondary outcomes are survival to hospital discharge and favourable neurological condition at hospital discharge defined by a cerebral performance category (CPC) of 1 or 2.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 237
• Est. completion date: December 31, 2022
• Est. primary completion date: October 20, 2022
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Hospitalized after out of hospital cardiac arrest
• Chest compressions received
• Chest imaging within the first 12 hours of admission

Exclusion Criteria:

• Traumatic cardiac arrest
• Chest trauma/surgery/pneumothorax one month prior to cardiac arrest

Related Conditions & MeSH terms

• Cardiac Arrest
• Heart Arrest
• Pneumothorax
• Resuscitation

Intervention

Procedure:
• Cardiopulmonary Resuscitation
Cardiopulmonary Resuscitation (Advanced Life Support) according to current guidelines

Locations

Country	Name	City	State
Austria	Medical University of Graz	Graz	Styria

Sponsors (1)

Lead Sponsor	Collaborator
Auinger, Daniel MD

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Presence of pneumothorax		within 12 hours of admission
Secondary	Survival		to hospital discharge (up to 2 months)
Secondary	Cerebral Performance Category		at hospital discharge (up to 2 months)