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Cannabis Dependence clinical trials

View clinical trials related to Cannabis Dependence.

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NCT ID: NCT04851392 Completed - Cannabis Use Clinical Trials

Do Adolescents and Adults Differ in Their Acute Response to Cannabis?

CannTeenA
Start date: March 11, 2019
Phase: N/A
Study type: Interventional

The acute effects of cannabis may differ between adolescents and adults. Furthermore, these effects may be tempered by the presence of cannabidiol. This double-blind, placebo-controlled, crossover experiment investigates the acute effects of cannabis (with and without cannabidiol) on subjective effects, behavioural responses and neural functioning in 16-17 year-olds and 26-29 year-olds who regularly use cannabis (0.5-3 days per week).

NCT ID: NCT04595318 Completed - Tobacco Dependence Clinical Trials

Varenicline for Co-occurring Cannabis and Tobacco Use

Start date: January 2015
Phase: Phase 4
Study type: Interventional

Pilot, eight week, open-label, within-subject cross over trial of four weeks of standard clinical care (SCC) in an outpatient substance abuse treatment program and four weeks of SCC and varenicline among current and former tobacco smokers with frequent cannabis use.

NCT ID: NCT04202146 Completed - Cannabis Dependence Clinical Trials

Cannabis Use and Relapse After One Week of Contingency Management Therapy

Start date: July 15, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effects of a seven-day combined contingency management (CM) with two sessions of brief Motivation Interviewing (MI) followed by standardized individual drug counseling on cannabis use and relapse in the following 90-day period in individuals with moderate to severe Cannabis Use Disorder (DSM-5).

NCT ID: NCT03662529 Completed - Opioid-use Disorder Clinical Trials

Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting

Start date: June 5, 2017
Phase: N/A
Study type: Interventional

This study was an internal program effectiveness evaluation of the effects of a four-session weekly individualized cognitive therapy program (called the "Mind Freedom Plan" (MFP)) on substance use outcomes and substance abuse treatment retention in Veterans admitted to an intensive outpatient treatment program for substance abuse at the Richmond Veterans Administration Medical Center (RICVAMC). Substance use and treatment retention metrics of MFP-assigned Veterans were compared with those of Veterans assigned to typical case-management-oriented weekly individual sessions.

NCT ID: NCT03104257 Completed - Healthy Clinical Trials

The Neural Correlates of Cannabis Use

Multimodal
Start date: December 2016
Phase:
Study type: Observational

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

NCT ID: NCT02946489 Completed - Cannabis Dependence Clinical Trials

Facilitating the Behavioral Treatment of Cannabis Use Disorder

Start date: October 2016
Phase: Phase 1
Study type: Interventional

Cannabis use disorders remain a significant public health problem. The pharmacological facilitation of behavioral treatment represents a promising strategy for addressing disordered cannabis use. Cannabis use disorders are recognized to be associated with various vulnerabilities that complicate the course of treatment and that may be amenable to glutamate modulators. The purpose of this single blind open-label trial is to test the feasibility of administering glutamate modulators in conjunction with motivational enhancement therapy (MET) and mindfulness based relapse prevention (MBRP) for cannabis use disorders.

NCT ID: NCT02711371 Completed - Cannabis Dependence Clinical Trials

Social and Emotional Brain Function in Cannabis Users

Start date: July 2015
Phase: N/A
Study type: Observational

The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.

NCT ID: NCT02210195 Completed - Clinical trials for Alcohol Use Disorder

Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence

Start date: July 2014
Phase: Phase 2
Study type: Interventional

The primary aim of the supplemental study is to provide POC testing of aprepitant as a treatment for comorbid alcohol and cannabis dependence. The data analysis plan specified in the parent grant will likewise be applied to the supplemental project to test for effects of aprepitant vs placebo on measures of alcohol and cannabis use and protracted withdrawal. The primary hypothesis is that subjects treated with aprepitant will have significantly less alcohol and marijuana use than subjects treated with placebo.

NCT ID: NCT02088177 Completed - Cannabis Dependence Clinical Trials

Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence

Start date: October 2014
Phase: Phase 1/Phase 2
Study type: Interventional

This is an 8 week, outpatient research study testing the use of long-acting naltrexone (Vivitrol) as a treatment for marijuana dependence. Vivitrol is a medication that is effective in treating dependence on opiates and opioids, and in treating dependence on alcohol. It is FDA approved for these disorders. It is a long-acting medication that contains enough medicine in each injection to last for one month. One way it works is by blocking the effects of opiates, including opiates released by the body in response to drugs and alcohol. In this study, we are interested in testing the effects of Vivitrol in people with marijuana dependence. Individuals participating in this study will receive two Vivitrol injections, each given four weeks apart, (week 1 and week 5). The injection is given in the muscle of the buttock on one side. Participants will attend clinic visits two times a week during this 8-week study for medical management for drug use and for monitoring of physical and psychological health.

NCT ID: NCT01875796 Completed - Anxiety Disorders Clinical Trials

Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders

Start date: June 2013
Phase: Phase 1
Study type: Interventional

This project tests the feasibility and utility of a novel, integrated approach to treatment of patients with cannabis use disorder (CUD) and anxiety disorders.