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NCT03350802 Clinical Trial

Procalcitonin Test for Differentiation of the Cause of Pneumonia

Cancer Clinical Trial

Official title:
Usefulness of Procalcitonin Test to Differentiate the Cause of Pneumonia in Patients With Cancers

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03350802
Other study ID # NCC2014-0018
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2014
Est. completion date June 30, 2020

Study information
Verified date September 2020
Source National Cancer Center, Korea
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to evaluate the usefulness of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

Description:

Serum procalcitonin test is currently used as the biomarker for bacterial infection. Especially, procalcitonin test has been reported to be helpful in differentiating bacterial pneumonia from viral pneumonia, acute exacerbations of interstitial pneumonitis or chronic obstructive lung disease. However, it is not known whether procalcitonin test can help distinguish bacterial pneumonia from non-bacterial pneumonia such as radiation pneumonitis or chemotherapy-induced pneumonitis in patients with cancer.

The aim of this prospective cohort study is to observe the clinical benefits of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

Recruitment information / eligibility
Status Completed
Enrollment 649
Est. completion date June 30, 2020
Est. primary completion date June 30, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Age greater than 18 years

- Patients who have symptoms and suspected imaging findings compatible with pneumonia

Exclusion Criteria:

- Patients who have been treated with antibiotics or steroid therapy.

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• procalcitonin test
All patients enrolled in this cohort undergo procalcitonin test in addition to basic microbiological test.

Locations
Country Name City State
Korea, Republic of Respiratory Clinic, National Cancer Center Goyang-si Gyeonggi-do

Sponsors (1)
Lead Sponsor Collaborator
National Cancer Center, Korea

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary Procalcitonin level according to the cause of pneumonia in patients with cancer bacterial pneumonia vs. radiation pneumonitis vs chemotherapy-induced pneumonitis procalcitonin level is checked within 24hours after visiting hospital
Secondary Influence of neutropenia on procalcitonin level in patients with baterial pneumonia bacterial pneumonia with neutropenia vs. without neutropenia procalcitonin level is checked within 24hours after visiting hospital
Secondary procalcitonin level in patients with atypical pneumonia viral pneumonia vs tuberculosis vs fungal infection procalcitonin level is checked within 24hours after visiting hospital
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