There are more than 498,563 clinical trials published worldwide with over 60,000 trials that are currently either recruiting or not yet recruiting. Use our filters on this page to find more information on current clinical trials or past clinical trials (free or paid) for study purposes and read about their results.
OSI-906 is a new drug that may stop cancer cells from growing abnormally. This drug has been used in other research studies and information from those suggests that OSI-906 may help block cell receptors involved in tumor growth. Gemcitabine and erlotinib are used as standard treatment for pancreatic cancer. In this research study, the investigators are looking for the highest dose of OSI-906 that can be given safely in combination with gemcitabine and erlotinib. This dose will then be given together with gemcitabine and erlotinib to a further group of patients with pancreatic cancer.
20% of Canadians are hypertensive with approximately 200,000 new cases each year. Early detection of hypertension affects outcomes, reducing the risk for heart attack, stroke, kidney disease, and dementia. Screening strategies are required to identify the more than one third of Canadians with unrolled high blood pressure, in particular, younger men unaware of their condition, women over sixty years old, and underserved groups. A collaborative practice model linking dentists to other healthcare providers in a reporting network is a promising model for hypertension detection and management. There are 20,129 licensed dentists in Canada who graduate with the ability to measure blood pressure, and 74% of the population visits a dentist each year. This represents an opportunity, but information is required on Dental attitudes toward screening for hypertension before attempting to initiate a screening model. To engage dentists in hypertension detection requires an understanding of the practice environment and the factors that shape their beliefs, attitudes and behaviours regarding routine hypertension screening in their practices.
In patients with an ovarian cancer, the treatment is currently based on surgery and chemotherapy. The impact of chemotherapy on the expansion and functional abilities of Vgamma9Vdelta2 T cells has never been evaluated. The long term goal is to give a rational to combine conventional treatment of ovarian cancer with immunotherapy based on Vgamma9Vdelta2 T cells.
The purpose of this study is to determine if pre-operative vitamin D supplementation lowers the incidence of post-operative transient or permanent hypoparathyroidism in patients undergoing total thyroidectomy.
Participants will be randomized to undergo a High Tibial Osteotomy (HTO) with or without a knee scope. Patients will be tested in the Gait Lab, will fill out quality-of-life questionnaires, and have a clinical evaluation done preoperative and at each follow-up visit.
The purpose of this study is to evaluate the efficacy and safety of two different drugs in the treatment of patients diagnosed with memory difficulties and a decline in cognitive function. This is a parallel distribution: a group of patients will be treated with a combination Panax Ginseng + Ginkgo Biloba + multivitamin + Polyminerals (EMS), and another group with Ginkgo Biloba (Tebonin ®).
The purpose of this study is to investigate a new treatment for non-cardiac chest pain (NCCP) related to gastrointestinal reflux disease (GERD), called Dexilant. The investigators would like to test its effectiveness in treating NCCP. The patient will undergo esophageal balloon distention testing (EBDT) before and after taking the new treatment for one month (Dexilant). EBDT evaluates the sensation and mechanical properties of the esophagus. A catheter with a deflated balloon is placed through the mouth and into the esophagus and the balloon is inflated with water. ECG and labs will be done throughout the study as a measurement of safety.
Primary Aims: 1. Evaluate HBV (Hepatitis B Virus) infection prevalence among Druze in the Galilee. 2. Educate the population in order to reduce transmission 3. Increase awareness among primary care providers Secondary Aims: 1. Identify chronic HBV infected patients who need to be followed and treated, 2. Identify HBV infected women in a childbearing age 3. Identify non immunized individuals and recommend vaccination 4. Identify previously vaccinated individuals who are not immunized 5. Identify previously vaccinated individuals who became infected Study Design: Study population is targeted to native Israeli Druze. We aim for evaluating up to 20,000 people from Druze communities in the Galilee area This work will be divided into three sections: 1. Increasing awareness: lectures and local events will be taken place in the communities. Written information will be given and primary care-providers mainly family doctors, nurses and obstetric surgeons will be involved. 2. All participants, upon signing a consent will: - Fill up a questioner - Checked for weight, height and waist circumflex - Have a blood sample taken 3. Results and recommendations will be forwarded to all participants
The processing of standard flexible nasopharyngoscopes is a time-consuming and costly process. The goal of this study is to determine the efficiency and cost-effectiveness of sheathed flexible endoscope in an office setting.
This study wants to determine the activity of a first-line treatment related to Thymidylate Synthetase (TS) Expression. Patients with the diagnosis of non-squamous advanced Non-Small-Cell Lung-Cancer (Stage IV) and without evidence of EGFR mutation may be enclosed in this clinical trial.