The Effect of Lt to Rt Shunt Using Veno-veno-arterial Extracorporeal Membrane Oxygenation (ECMO) on Coronary Oxygenation in Lung Transplantation Patients

Bronchiectasis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02859194
• Other study ID #: 4-2016-0124
• Status: Completed
• Phase: N/A
• Start date: May 31, 2016
• Est. completion date: October 14, 2016

Study information

• Verified date: July 2018
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

ECMO(Extracorporeal membrane oxygenation) is being essential for cardiopulmonary failure patients. There are two types of ECMO, which is veno-veno (V-V) that can be used in respiratory failure patients and veno-arterial (V-A) that can be used in cardiac failure patients. V-A ECMO can also be used during lung transplantation, substitution of cardiopulmonary bypass, which can show sufficient performance during operation and better postoperative outcome. However, regarding V-A ECMO circulating from femoral vein to femoral artery, there is a pro blem of differential hypoxia which might influence coronary artery and head vessels. In this prospective study, the investigators are planning to put another ECMO catheter into internal jugular vein which takes a role of left to right shunt, to mitigate the hypoxia of coronary artery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: October 14, 2016
• Est. primary completion date: October 14, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

1. scheduled for double lung transplantation

Exclusion Criteria:

1. patients who have history of coronary artery occlusive disease

2. patients with arrhythmia

Related Conditions & MeSH terms

• Acute Lung Injury
• ARDS (Acute Respiratory Distress Syndrome)
• Bronchiectasis
• COPD (Chronic Obstructive Pulmonary Disease)
• Familial Primary Pulmonary Hypertension
• Hypertension, Pulmonary
• Interstitial Pulmonary Fibrosis ARDS
• Lung Diseases
• Lung Diseases, Interstitial
• Lung Diseases, Obstructive
• Lymphangioleiomyomatosis
• Primary Pulmonary Hypertension
• Pulmonary Disease, Chronic Obstructive
• Pulmonary Fibrosis
• Respiratory Distress Syndrome, Adult
• Respiratory Distress Syndrome, Newborn

Intervention

Procedure:
• Veno-veno-arterial ECMO

Locations

Country	Name	City	State
Korea, Republic of	Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	arterial blood oxygen partial pressure (PaO2)		5 min after jugular catheter flow 0ml/min
Primary	arterial blood oxygen partial pressure (PaO2)		5 min after jugular catheter flow 500 ml/min
Primary	arterial blood oxygen partial pressure (PaO2)		5 min after jugular catheter flow 1,000ml/min
Primary	arterial blood oxygen partial pressure (PaO2)		5 min after jugular catheter flow 1,500ml/min
Secondary	venous blood oxygen partial pressure (PvO2)		5 min after jugular catheter flow 0ml/min
Secondary	venous blood oxygen partial pressure (PvO2)		5 min after jugular catheter flow 500 ml/min
Secondary	venous blood oxygen partial pressure (PvO2)		5 min after jugular catheter flow 1,000ml/min
Secondary	venous blood oxygen partial pressure (PvO2)		5 min after jugular catheter flow 1,500ml/min