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Breast Neoplasms clinical trials

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NCT ID: NCT02735668 Completed - Breast Cancer Clinical Trials

Physiotherapy in Women With Peripheral Persistent Pain Following Breast Cancer Treatment

Start date: April 2016
Phase: N/A
Study type: Interventional

The aim of this study is to determine the effectiveness of a multimodal physiotherapy intervention including scapula exercises in addition to deep dry needling and neurodynamic techniques versus scapula exercises only versus conventional shoulder exercises on pain intensity, perceived disability, scapula muscle activity and health-related quality of life.

NCT ID: NCT02733601 Completed - Breast Cancer Clinical Trials

Epidemiology of Breast Cancer in Women Based on Diagnosis Data From Oncologists and Breast Surgeons in Algeria

BreCaReAl
Start date: May 29, 2016
Phase:
Study type: Observational [Patient Registry]

National, prospective, multicentre, non-interventional epidemiological study, conducted among oncologists and breast surgeons in community and university hospitals, from the public sector in Algeria. The study will collect information on the characteristics, and breast carcinomas patterns of patients whose breast cancer diagnosis was confirmed by an anatomopathologist. The study will be conducted over a representative, but not exhaustive sample of Algerian female patients.

NCT ID: NCT02732119 Completed - Breast Cancer Clinical Trials

Study of Ribociclib With Everolimus + Exemestane in HR+ HER2- Locally Advanced/Metastatic Breast Cancer Post Progression on CDK 4/6 Inhibitor.

TRINITI-1
Start date: June 14, 2016
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is determine if the triplet combination of ribociclib, everolimus and exemastane is safe and effective in the treatment of locally advanced/metastatic breast cancer following treatment with a CDK 4/6 inhibitor

NCT ID: NCT02730858 Completed - Clinical trials for Metastatic Breast Cancer

Palliative And Oncology Care Model In Breast Cancer

Start date: May 2016
Phase: N/A
Study type: Interventional

The purpose of this research study is to test a new way to deliver oncology and palliative care for patients with metastatic breast cancer. - The goal of this study is to test a model where oncology and palliative care work together to care for participants with metastatic breast cancer who were recently admitted to the hospital or have new or worsening cancer involving their brain or the fluid around the brain or spinal cord. - The investigators are studying whether participants who receive care from both teams have better communication about their care and improved quality of life and mood compared to those receiving care from only their oncologists. The purpose of this randomized clinical trial is to conduct a randomized trial testing the impact of the collaborative palliative and oncology care model or standard oncology care models among patients with poor prognosis metastatic breast cancer. Participants assigned to the intervention arm will participate in a series of structured palliative care visits, following tailored clinical practice guidelines previously developed for patients with metastatic breast cancer.

NCT ID: NCT02730130 Completed - Breast Cancer Clinical Trials

Study to Assess the Efficacy of Pembrolizumab Plus Radiotherapy in Metastatic Triple Negative Breast Cancer Patients

Start date: June 3, 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to find out what effects, good and/or bad, pembrolizumab has on the patient and areas of cancer in their body that did not receive radiation therapy.

NCT ID: NCT02729701 Completed - Breast Cancer Clinical Trials

Pilot Study of the Effect of Duavee® on Benign Breast Tissue Proliferation

Start date: May 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to learn whether daily use of Duavee® is accepted and tolerated by peri- and post-menopausal women at moderate risk for development of breast cancer.

NCT ID: NCT02728596 Completed - Clinical trials for Stage IV Breast Cancer

S1415CD, Trial Assessing CSF Prescribing Effectiveness and Risk (TrACER)

TrACER
Start date: October 7, 2016
Phase: N/A
Study type: Interventional

This randomized clinical trial studies prophylactic colony stimulating factor management in patients with breast, colorectal or non-small cell lung cancer receiving chemotherapy and with risk of developing febrile neutropenia. Patients receiving chemotherapy may develop febrile neutropenia. Febrile neutropenia is a condition that involves fever and a low number of neutrophils (a type of white blood cell) in the blood. Febrile neutropenia increases the risk of infection. Colony stimulating factors are medications sometimes given to patients receiving chemotherapy to prevent febrile neutropenia. Colony stimulating factors are given to patients based on guidelines. Some clinics have an automated system that helps doctors decide when to prescribe them when there is a high risk of developing febrile neutropenia. Gathering information about the use of an automated system to prescribe prophylactic colony stimulating factor may help doctors use colony stimulating factor when it is needed.

NCT ID: NCT02723877 Completed - Clinical trials for Metastatic Breast Cancer

PQR309 and Eribulin in Metastatic HER2 Negative and Triple-negative Breast Cancer (PIQHASSO)

Start date: March 28, 2016
Phase: Phase 1/Phase 2
Study type: Interventional

This study is an open-label,non randomized, multi-center, phase 1/2b (dose escalation followed by expansion part) study evaluating clinical safety, efficacy and pharmacokinetics of PQR309 in combination with standard dose of eribulin in patients with locally advanced or metastatic HER2-negative (escalation part) and Triple Negative Breast Cancer (expansion part).

NCT ID: NCT02721433 Completed - Breast Cancer Clinical Trials

4-weekly Versus 12-weekly Administration of Bone-targeted Agents in Patients With Bone Metastases

REaCT-BTA
Start date: August 2016
Phase: Phase 4
Study type: Interventional

The current Rethinking Clinical Trials (REaCT) trial will compare two schedules(12- vs. 4-weekly) of bone-targeting agents (BTAs) to evaluate quality of life, pain and skeletal events within the Canadian Health Care System. This study will use an "integrated consent model" that involves "oral consent" rather than a written informed consent writing process as the study is comparing standard schedules and not a new administration schedule.

NCT ID: NCT02721147 Completed - Breast Cancer Clinical Trials

Pilot Study of an Intimacy Enhancement Intervention for Couples Facing Breast Cancer

Start date: October 27, 2015
Phase: N/A
Study type: Interventional

The central goal of this study is to examine the feasibility, acceptability, and preliminary efficacy of the IE intervention on patient and partner sexual QOL and relationship outcomes, and on patient psychosocial outcomes. We expect that the IE will show adequate feasibility, acceptability, and preliminary efficacy. Secondarily, based on the rationale that barriers exist that limit participation in intensive sexual QOL interventions for breast cancer survivors, an innovative secondary aim will investigate the perspectives of study-eligible patient candidates who opt out of participating in the pilot trial. We expect that we will be able to identify the participation barriers and intervention preferences of breast cancer survivors with sexual concerns who opt out of the intensive trial in order to inform the development of different interventions for future study.