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Clinical Trial Summary

This study aims to utilize a novel biomarker-driven approach to guide neoadjuvant treatment selection. It is the hypothesis that this will improve clinical response for postmenopausal women with clinical stage II/III ER-positive, HER2-negative breast cancer and identify those who may not require neoadjuvant chemotherapy, with a primary focus on outcomes in Black patients.


Clinical Trial Description

Risk category is defined as follows: - Low risk: - Baseline Ki67 ≤ 10% (OR) - Luminal A molecular intrinsic subtype by PAM50 - High risk: - Non-Luminal A molecular intrinsic subtype by PAM50 (OR) - In cases of non-diagnostic PAM50 molecular intrinsic subtype, patients will enroll in the high-risk group and undergo Week 4 tumor biopsy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05837455
Study type Interventional
Source Washington University School of Medicine
Contact Nusayba A Bagegni, M.D.
Phone 314-273-3022
Email nbagegni@wustl.edu
Status Recruiting
Phase Phase 2
Start date May 30, 2024
Completion date November 30, 2027

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