Breast Cancer Clinical Trial
Official title:
Diagnostic and Prognostic Value of MicroRNA as a Potential Biomarker in Breast Cancer Patients in Correlation to Radiological Findings.
The aim of this study is to evaluate the role of miRNA 125a -5p and miRNA143-3p as a non invasive biomarker in diagnosis of breast cancer and the relationship between MiRNA expression and histopathological features as tumor stage ,grade ,molecular subtypes. Also trying to correlate the results with MRI radiological findings which may help in better selection of treatment protocols.
Status | Not yet recruiting |
Enrollment | 50 |
Est. completion date | March 1, 2024 |
Est. primary completion date | March 1, 2023 |
Accepts healthy volunteers | |
Gender | Female |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: 1. control group of normal healthy individuals who don't have tumors in other organs. 2. breast cancer group Patients with confirmed breast cancer who didn't receive radiotherapy ,chemotherapy ,hormonal therapy or surgical treatment. Exclusion Criteria: 1. Patients refuse to be part of study and undergo examination . 2. All patients with breast cancer that had received chemotherapy, radiotherapy , ,hormonal or surgical treatment. 3. History of benign or malignant tumors in other organs |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12. Erratum in: CA Cancer J Clin. 2020 Jul;70(4):313. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | assessment of the value of MiRNA in diagnosis and prognosis of breast cancer patients | To evaluate diagnostic and prognostic role of MiRNA 125a-5p and 143-3p as a non invasive biomarker in breast cancer | 18-24 month | |
Primary | correlat MiRNA expression with MRI findings for better selection of treatment plan and out come | Also trying to correlate the results with MRI radiological findings which may help in better selection of treatment protocols. | 18-24 months |
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