Breast Cancer Clinical Trial
Official title:
Ketotifen: Novel Use as a Cardioprotective Agent in Breast Cancer Patients Receiving Anthracycline-containing Chemotherapy as Well as the Potential Beneficial Effects of Ketotifen in the Hypothetical Management of COVID-19
The objective of our study was to evaluate the expected cardioprotective effects of ketotifen due to its activity as an iron-chelating agent previously uncovered by us in the in vitro chemical test which included in the study, when used in patients receiving anthracyclines for the treatment of breast cancer. The study was a randomized : , prospective controlled trial : , and the patients were identified by coded numbers to maintain privacy. Eligible patients (111) fulfilled the criteria. Control Group: 55 patients received their standard therapy (anthracycline-containing chemotherapy without ketotifen). Ketotifen Group: 56 patients received anthracycline-containing chemotherapy plus ketotifen as a cardioprotective agent. Ketotifen will be given orally as one tablet (1 mg/tablet) 3 times daily, before and during the chemotherapeutic cycle for 6 cycles of treatment. Blood samples were obtained from all patients, and echocardiography two times for each patient at baseline and after 6 months (EF%).
The objective of our study was to evaluate the expected cardioprotective effects of ketotifen
due to its activity as an iron-chelating agent previously uncovered by us in the in vitro
chemical test which included in the study, when used in patients receiving anthracyclines for
the treatment of breast cancer. The study was a randomized : , prospective controlled trial :
, and the patients were identified by coded numbers to maintain privacy. Eligible patients
(111) fulfilled the criteria. Control Group: 55 patients received their standard therapy
(anthracycline-containing chemotherapy without ketotifen). Ketotifen Group: 56 patients
received anthracycline-containing chemotherapy plus ketotifen as a cardioprotective agent.
Ketotifen will be given orally as one tablet (1 mg/tablet) 3 times daily, before and during
the chemotherapeutic cycle for 6 cycles of treatment. Blood samples were obtained from all
patients, and echocardiography two times for each patient at baseline and after 6 months
(EF%).
The aim is to prove and evaluate the prophylasis effect of ketotifin from cardiotoxicity
induced by anthracyclines therapy without decreasing the anti-tumor action of anthracycline.
Because coronaviruses theoretically induce iron overload so, ketotifen has a potential
beneficial effect in the management of COVID-19 as well.
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