Breast Cancer Clinical Trial
Official title:
Cardioprotection of Silymarin for Patients Received Anthracycline Chemotherapy
the study aim to protect patients received anthracyclines containing chemotherapy from cardiotoxcity induced by anthracyclines derivatives. by using L-carnitine and Silymarin for protection the heart from anthracyclines toxicities, and in addition its a comparitive study between L-carnitine and Silymarin.
Aim: Anthracycline induced cardiotoxicity is the most common constrains of its use in
treatment of various types of cancer. This study aimed to investigate benefits from adding
L-carnitine and Silymarin compared to anthracycline chemotherapy alone in patients with
cancer.
Methods: 83 patients were recruited from Clinical Oncology Department, Tanta University,
Egypt, then prospectively randomized to receive their anthracycline containing therapeutic
regimen, control group (n=33) or anthracycline plus L-carnitine, L-carnitine group (n=25), or
anthracycline plus Silymarin, Silymarin group (n= 25). Blood samples were collected at
begging and after 6 months to measure LDH, CK-MB, cTn I, Anticardiolipin IgG, Fe, ferritin
and TIBC and % of saturation. % EF was documented. Data were statistically analyzed by ANOVA
and paired t test. P <0.05 was statistically significant.
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