Breast Cancer Clinical Trial
Official title:
A Randomized, Open Label Trial to Evaluate Radical Local Treatment Versus Palliative Treatment for Breast Cancer Patients With Ipsilateral Humerus or Sternum Oligometastasis
A Randomized, Open Label, Phase III Trial to Evaluate Radical Local Treatment versus Palliative Treatment for Breast Cancer Patients with Primary Ipsilateral Humerus or Sternum Oligometastasis
This is a prospective, randomized, and multicenter study to compare the radical local
treatment versus palliative treatment for breast cancer patients with primary ipsilateral
humerus or sternum oligometastasis.
183 subjects will be randomized divided into two groups (experimental group and control
group) at a ratio of 2 to 1.
Control group: Palliative treatment. No radical surgical resection or radiotherapy is
performed in this group. But palliative internal fixation or radiotherapy for pain relief is
permitted. Moreover, systemic chemotherapy, endocrine therapy and targeted therapy are
allowed.
Experimental group：Radical local treatment. Radical resection is performed, and the cutting
edge is negative, or radical local radiotherapy is feasible (cumulative radiotherapy dose is
greater than or equal to 50Gy). Systemic endocrine therapy and targeted therapy are allowed
after radical local therapy. However, whether systemic chemotherapy should be used is
determined by clinicians according to clinical experience or guidelines.
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