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Durvalumab With Trastuzumab and Pertuzumab in HER2-Enriched Breast Cancer — DTP  

Breast Cancer Clinical Trial

Official title:
Multicenter Phase II Trial of Durvalumab (MEDI4736) With Trastuzumab and Pertuzumab Combination in HER2-Enriched and HER2-Amplified Breast Cancer (DTP Trial)

Clinical Trial Summary

The purpose of this research study is to test the safety and effectiveness of using durvalumab with trastuzumab and pertuzumab in participants with human epidermal growth factor receptor 2 (HER2)-enriched breast cancer.

Clinical Trial Description

The purpose of this research study is to test the safety and effectiveness of using durvalumab with trastuzumab and pertuzumab in participants with HER2-enriched breast cancer. The standard or usual pre-surgery treatment for this type of disease are drugs called trastuzumab and pertuzumab that target HER2. Studies have shown that trastuzumab and pertuzumab treatment can stimulate the body's own immune system to attack cancer cells. Durvalumab is a drug that also activates the immune system. The use of durvalumab together with trastuzumab and pertuzumab treatment may allow the immune system to work harder to kill cancer cells. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03820141
Study type Interventional
Source The Methodist Hospital Research Institute
Contact Houston Methodist Cancer Center
Phone 713-441-0629
Email ccresearch@houstonmethodist.org
Status Recruiting
Phase Phase 2
Start date March 3, 2020
Completion date February 2025
View Details
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