Relationship Between Gut Microbiome & Adjuvant Chemotherapy in Patients

Status Terminated

Clinical Trial Summary

Clinical Trial Description

Breast cancer is the most common cause of cancer death in women. Adjuvant chemotherapy significantly reduces the risk of recurrence of high-risk breast cancer. However, about 30% of patients still have distant metastasis or local recurrence after chemotherapy. Moreover, 60% of patients had 3-4 degrees of adverse drug reactions during chemotherapy. The human gut microbiota have been considered the most important microecosystem living in symbiosis with the body. It is identified as a crucial determinant in cancer occurrence and development . Besides, Gut microbial alterations may influence the therapy efficacy and adverse drug event. We collect the fresh tail stool sample 24h before adjuvant chemotherapy and 24h after adjuvant chemotherapy then the composition of intestinal microbiota and subsequent short-term alterations are analysed by 16srRNA sequencing.The purpose of the study is to investigate relationship between gut microbiome and adjuvant chemotherapy in early breast cancer patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03702868
Study type	Observational
Source	Sun Yat-sen University
Contact
Status	Terminated
Phase
Start date	October 10, 2018
Completion date	October 30, 2020

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Relationship Between Gut Microbiome and Adjuvant Chemotherapy in Patients With Early Breast Cancer

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms