Breast Cancer Clinical Trial
Official title:
Developing a Healthy Lifestyle in Breast Cancer Survivors
At this time, no study has examined the effect of a lifestyle intervention with a reduced
Sedentary Behavior (SB) prescription on overall physical activity, weight loss, metabolic
dysfunction, and inflammation in breast cancer survivors. Thus, in collaboration with
University of Tennessee Medical Center's (UTMC) Cancer Institute, investigators propose to
randomize 30 female breast cancer survivors (history of breast cancer stages I [> 1 cm], II,
or III) with a body mass index (BMI) between 25 and 45 kg/m2 who are sedentary (engage in > 8
hours a day of SB) and inactive (engage in < 100 min/wk MVPA) to one of three, 3-month
conditions:
1. lifestyle intervention (Lifestyle) (increase MVPA to > 200 min/wk);
2. lifestyle intervention with a reduced SB prescription (Lifestyle+SB) (increase MVPA to >
200 min/wk and reduce SB by 2 hrs/day); or
3. weight management education materials provided via mailed newsletter (Newsletter).
Lifestyle and Lifestyle+SB will receive a standard dietary (low-calorie [1200-1500 kcal/day],
low-fat [<30% calories from fat]) prescription that emphasizes intake of fruits, vegetables,
and whole grains, and a cognitive behavioral intervention to assist with meeting activity and
diet goals. Dependent variables, measured at 0 and 3 months, include objectively measured SB,
LPA, MVPA, and total activity via accelerometry; self-reported SB; percent weight loss;
insulin and glucose, and leptin and C-reactive protein (CRP) (biomarkers of cancer prognosis
that have been found to be positively related to SB and/or adiposity); diet; body
composition; and fitness.
n/a
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