Breast Cancer Clinical Trial
Official title:
Long-term Outcome of HER2-amplified Metastatic Breast Cancer: A Retrospective Analysis
The aim of this study is to analyze cases of human epidermal growth factor receptor (HER) 2-positive metastatic breast cancer (MBC) of the last 10 years at the University Hospital of Zurich to assess the efficacy of the treatment with trastuzumab in HER2-positive MBC and to find out associations between different variables and the outcome. The aim is to find out probable prognostic factors and patterns of disease progression. Prognostic factors could optimize treatment approaches and result in a delay of disease progression.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | February 2016 |
Est. primary completion date | September 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Received at least 1 dose of trastuzumab in metastatic setting at the University hospital of Zurich from 01/2004 to 12/2014. - HER2+ status confirmed by immunohistochemistry (IHC) 3+ or fluorescence in situ hybridization (FISH) = 2. Exclusion Criteria: |
Observational Model: Cohort, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
Switzerland | UniversitätsSpital Zürich, Klinik für Gynäkologie | Zurich |
Lead Sponsor | Collaborator |
---|---|
University of Zurich |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Time to disease progression | time from commencing trastuzumab (or other anti-HER2 therapy) to the time of disease progression or death | up to 120 months | No |
Secondary | Response duration | up to 120 months | No |
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