Chimeric Antigen Receptor-Modified T Cells for Breast Cancer

Status Withdrawn

Clinical Trial Summary

The purpose of this study is to evaluate the safety and efficacy of HER2-CAR-T cell Infusion for advanced HER2 positive breast cancer.

Clinical Trial Description

By enrolling patients with advanced HER2 positive breast cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of HER2-CAR-T cell infusion for advanced HER2 positive breast cancer.The CAR consists of a HER-2 targeting antibody scFv with two intracellular signaling domains derived from CD3 zeta and CD28. Autologous T cells will be gene-engineered with the CAR gene using a retrovirus vector. Prior to T cell infusion, the patients will be subjected to preconditioning treatment. After T cell infusion, the patients will be evaluated for 24 months for adverse reactions, persistence of CAR T cells and efficacy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02547961
Study type	Interventional
Source	Fuda Cancer Hospital, Guangzhou
Contact
Status	Withdrawn
Phase	Phase 1/Phase 2
Start date	September 2015
Completion date	August 15, 2016

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