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Phase I of Carboplatin-Olaparib Followed by Olaparib Monotherapy in Advanced Cancer — REVIVAL  

Breast Cancer Clinical Trial

Official title:
A Phase I Followed by a Randomized Phase II Trial of Two Cycles Carboplatin-Olaparib Followed by Olaparib Monotherapy Versus Capecitabine in BRCA-1 or -2 Mutated Her2 Negative Advanced Breast Cancer as First Line Treatment

Clinical Trial Summary

A phase I trial to determine the recommended phase two dose of the combination of carboplatin and olaparib.

Clinical Trial Description

A 3+3 dose escalation trial of 2 cycles (21 days) carboplatin and olaparib combination therapy, followed by olaparib monotherapy until progression or unacceptable toxicity in patients with advanced cancer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02418624
Study type Interventional
Source The Netherlands Cancer Institute
Contact
Status Completed
Phase Phase 1
Start date May 2015
Completion date January 2019
View Details
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