Breast Cancer Clinical Trial
Official title:
Impact of Recurrence Score® on Recommendations for Adjuvant Treatment in Patients With ER-positive Breast Cancer
Oncotype DX® is likely to become more widely used in Europe as well as in Switzerland. The
test is currently not reimbursed by the Swiss health insurances.
The proposed study will investigate to what extent adjuvant treatment recommendations in
breast cancer patients with an ER-positive tumor, made by Swiss tumor boards, are based on
conventional factors, and whether the recommendations would change, when RS results from the
Oncotype DX® test were available.
In addition this study approaches the dilemma of adding adjuvant CT to adjuvant endocrine
therapy in a systematic fashion. In this study, the St. Gallen consensus 2009 (with a minor
update from the 2011 consensus, is used to predefine the patients suitable for endocrine
therapy or chemo-endocrine therapy. Once results of this study are available they may help to
better integrate Oncotype DX® with other factors. Currently, it is unclear how the different
factors should be integrated into one recommendation.
This study will provide data on the usefulness of this test for the two patient groups which
are suitable for hormone therapy only and for those who are considered for hormone plus
chemotherapy.
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