Ovarian Reserve in Premenopausal Breast Cancer

Status Terminated

Clinical Trial Summary

This is a translational, mutlicentre study. The aim of this study is to determine whether pre-treatment levels of hormones predict ovarian follicular reserve post adjuvant or neoadjuvant chemotherapy for breast cancer and chemotherapy induced amenorrhea.

Clinical Trial Description

It is proposed that levels of AMH and inhibin A and B measured will give an indication of the residual ovarian reserve in women with breast cancer treated with chemotherapy. In addition, AMH might give an indication of the possible efficacy of GNRH agonists in fertility preservation and the effect on ovarian follicular reserve using different adjuvant chemotherapy regimens. Those likely to be offered GNRH agonists are younger women with no children and a wish to have some in the future. Older women who have completed their families are less likely to be offered a GNRH agonist. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01726322
Study type	Observational
Source	Cancer Trials Ireland
Contact
Status	Terminated
Phase
Start date	September 2012
Completion date	July 13, 2020

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