Breast Cancer Clinical Trial
Official title:
Circulating miRNAs as Biomarkers of Hormone Sensitivity in Breast Cancer? Pilot Study.
This is a biomedical and prospective study of interventional type. The trial will include 29
patients over a period of 15 months + 24 months of follow up maximum.
The study will be conduct in womens with metastatic invasive breast cancer or locally
advanced breast cancer and for which treatment with tamoxifen or anti aromatase (first line
hormone therapy for metastatic breast cancer) is indicated.
The main objective of this pilot study is to evaluate the feasibility to detect in the
circulating blood of patients, before treatment (T0), the presence of the fifteen tissular
microRNAs described in preclinical studies as possibly involved in hormone
resistance/sensitivity.
In parallel of the detection of these specific miRNAs, we will conduct a larger scale
analysis of circulating miRNAs in these patients before (T = 0) and after one month of
treatment (T28).
n/a
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