Breast Cancer Clinical Trial
Official title:
Adjuvant Chemotherapy Combined With Trastuzumab in the Randomized Phase III Trial N9831 Actively Immunizes Patients Against Tumor Antigens
RATIONALE: Studying samples of blood and DNA in the laboratory from patients who received
chemotherapy with or without trastuzumab may help doctors learn more about the effects of
trastuzumab on cells. It may also help doctors understand how well patients respond to
treatment.
PURPOSE: This research trial studies blood and DNA samples from patients with breast cancer
treated with chemotherapy with or without trastuzumab.
OBJECTIVES:
- To determine the role of trastuzumab in the generation of HER2-specific antibodies in
breast cancer patients undergoing adjuvant combination therapy.
- To determine whether the improved disease-free period and overall survival of patients
treated in the adjuvant setting with combination of chemotherapy and trastuzumab is
dependent on the Fcγ receptor genotype of the patient.
OUTLINE: Previously collected serum and DNA samples are analyzed for HER2-specific antibodies
and FcγR genotype by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction
(PCR).
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