Breast Cancer Clinical Trial
Official title:
Epigenetic Factors Associated With Symptoms and Complications of Chronic Disorders
This study examines the relationship among epigenetic alterations and the development and
persistence of psychoneurologic symptoms (cognitive dysfunction, depressive symptoms,
anxiety, fatigue, sleep disturbance, and pain) in women receiving chemotherapy for early
stage breast cancer. The relationship among inflammatory markers and psychoneurologic
symptoms will also be explored. It is hypothesized:
1. Chemotherapy triggers inflammatory activation, which in turn leads to the acquisition
of genetic alterations. These alterations result in cellular changes and are modified
over time.
2. Inflammatory activation and epigenetic alterations are related to the temporal
development, severity, and persistence of psychoneurologic symptoms.
Advancements in breast cancer have resulted in increased survival rates; however, many women
with breast cancer experience distressing symptoms. Inflammatory activation and epigenetic
alterations have been associated with the etiology of cancer. To date, no investigators have
considered these epigenetic processes as possible mechanisms associated with the etiology of
distressing symptoms in women with breast cancer. The specific aims of this study are to
examine:
1. The frequency and severity of psychoneurological (PN) symptoms (depressive symptoms,
anxiety, sleep disturbances, fatigue, pain and cognitive dysfunction)and the
interrelationship among PN symptoms at each time point
2. Levels of inflammation and to quantify the frequency and genome-wide location of
changes in epigenetic patterns across time following chemotherapy
3. The relationship among inflammation, epigenetic changes, and the development, severity,
and persistence of PN symptoms across time The study results may potentially deepen
understanding regarding the biological processes underlying PN symptoms and lead to
improved strategies for symptom management in women with breast cancer.
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