Breast Cancer Clinical Trial
Official title:
Cognition in Breast Cancer Patients: The Impact of Cancer-related Stress
The study will investigate the impact of cancer-related stress and its consequences (acute and posttraumatic stress symptoms, altered cortisol secretion) on cognitive function in breast cancer patients. The hypothesis that stress associated with the cancer diagnosis and the cancer treatment is a major cause of cognitive dysfunction in breast cancer patients shall be evaluated.
Primary hypothesis:
*The adverse effects of cancer and cancer therapy on cognitive function in breast cancer
patients are entirely or partly mediated by stress and the ensuing dysfunction of the
HPA-axis.
Secondary objectives:
- Determining the effect of cancer diagnosis, chemotherapy, disease-related stress, acute
stress response, posttraumatic stress disorder, posttraumatic stress symptoms, anxiety,
and depression on the HPA-axis in breast cancer patients
- Determining the effect of cognitive dysfunction assessed with neuropsychological tests,
cancer diagnosis, chemotherapy, disease-related stress, acute stress response,
posttraumatic stress disorder, posttraumatic stress symptoms, anxiety, and depression
on subjective cognitive function in breast cancer patients
- Prevalence of acute stress response, posttraumatic stress disorder and posttraumatic
stress symptoms, and extent of cancer-specific stress in breast cancer patients treated
with or without chemotherapy
;
Observational Model: Case Control, Time Perspective: Prospective
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