Breast Cancer Clinical Trial
Official title:
Evaluation of the Expression of the Cancer Stem Cell Marker ALDH1 as a Predictor of Adjuvant Chemotherapy Response in Breast Cancers of High Risk Women in SWOG-9313
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how patients enrolled on clinical trial SWOG-9313
will respond to doxorubicin and cyclophosphamide.
PURPOSE: This laboratory study is looking at tumor tissue samples from women with
early-stage breast cancer enrolled on clinical trial SWOG-9313.
OBJECTIVES:
Primary
- To determine if ALDH1 positivity, as determined by IHC staining, identifies a poor
prognostic subgroup of women with early-stage breast cancer who have been uniformly
treated with adjuvant doxorubicin and cyclophosphamide on clinical trial SWOG-9313.
Secondary
- To determine associations of ALDH1 expression with other known factors that have been
determined on clinical trial SWOG-9313, such as estrogen receptor (ER) status, HER2
status, TOPOII, cyclin E, and p27.
- To determine if ALDH1 positivity, as determined by IHC staining, identifies a poor
prognostic subgroup within ER and HER2 subgroups in patients treated on clinical trial
SWOG-9313.
OUTLINE: This is a multicenter study.
Tumor tissue samples from clinical trial SWOG-9313 are analyzed for ALDH1 expression by IHC.
;
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