Breast Cancer Clinical Trial
Official title:
Developing In-Vivo Models of Human Breast Cancer
RATIONALE: Changing the genes in laboratory mice to create a living model of human breast
cancer may help doctors learn more about breast cancer.
PURPOSE: This research study is developing mouse models of breast cancer using tissue samples
that were previously collected from women with breast cancer.
OBJECTIVES:
- To develop new in vivo models of human breast cancer.
- To correlate response in this model to actual treatment outcome in patients, if the in
vivo model is proven feasible.
OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule
site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish
metastatic spread patterns, and both histologic and molecular tumor characteristics.
Patients' medical charts are reviewed to obtain relevant information, including general
demographics, smoking and alcohol use, as well as outcome data such as survival and response
to treatment.
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