Study of Statin as Neo-Adjuvant Therapy in Postmenopausal Breast Cancer

Status Completed

Clinical Trial Summary

The purpose of this study is to monitor:

- Tumor biological alterations following two weeks of neo-adjuvant statin therapy.

- Effects of statins on tumor proliferation.

- Functional studies on the mevalonate pathway.

Clinical Trial Description

Blood samples and three core biopsies are taken after diagnosis. Treatment with atorvastatin at a daily dosis of 80 mg is initiated 14 days before planned surgery. Translational research will be performed from the core biopsy and blood samples taken before surgery and from the specimen from surgery. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00816244
Study type	Interventional
Source	Lund University Hospital
Contact
Status	Completed
Phase	Phase 2
Start date	January 2009
Completion date	March 2012

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