Breast Cancer Clinical Trial
Official title:
The Effect of Aromatase Inhibition on the Cognitive Function of Older Patients With Breast Cancer
RATIONALE: Gathering information about cognitive function over time in postmenopausal women
with breast cancer may help doctors learn about the long-term effects of aromatase inhibitor
therapy and plan the best treatment.
PURPOSE: This clinical trial is studying cognitive function in older postmenopausal women
with stage I, stage II, or stage III breast cancer receiving hormone therapy and in healthy
volunteers.
OBJECTIVES:
- Explore the impact of treatment with an aromatase inhibitor on the cognitive function
of postmenopausal women with stage I-III breast cancer vs in cancer-free, age-matched
healthy volunteers.
OUTLINE: Patients receive adjuvant anastrozole or letrozole in the absence of disease
progression or unacceptable toxicity.
Patients and healthy volunteers undergo cognitive function testing consisting of
neuropsychological battery tests and complete self-reported questionnaires (e.g., Squire
Memory Self-Rating Questionnaire, and FACT-B Quality of Life Measure) regarding cognitive
ability, quality of life, fatigue, and psychosocial status. Patients and healthy volunteers
also undergo geriatric assessment at baseline and after 6 months of initiation with
aromatase inhibitor therapy.
;
Observational Model: Case Control, Time Perspective: Prospective
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