Breast Cancer Clinical Trial
Official title:
Metronomic Chemotherapy With Bevacizumab for Advanced Breast Cancer
This randomized phase II trial is studying metronomic low-dose cyclophosphamide and methotrexate to see how well they work compared to metronomic low-dose cyclophosphamide, methotrexate, and bevacizumab in treating women with metastatic breast cancer.
This study uses an investigational drug called Bevacizumab. Investigational means that this
drug is not approved by the Federal Drug Administration and is still being studied.
Bevacizumab is the common name for the commercial drug Avastin. The Bevacizumab used in this
trial, however, is for use in research studies only and may be made at locations different
from those where Avastin is made. Although some differences may exist, bevacizumab for
research use and the commercial drug, Avastin, are manufactured by a similar process, meet
similar standards for final product testing, and are expected to be very similar in safety
and effectiveness.
The purpose of this study is to find out what effects (good and bad) low-dose continuous
chemotherapy (referred to as metronomic chemotherapy) using drugs Cytoxan (also called
cyclophosphamide) and methotrexate (CM), with or without bevacizumab.
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