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Genotyping and Phenotyping of CYP2D6 Breast Cancer Patients on Tamoxifen

Breast Cancer Female Clinical Trial

Official title:
Genotyping and Phenotyping of CYP2D6 as Predictor of Z-endoxifen Plasma Levels in Breast Cancer Patients on Tamoxifen Treatment

Clinical Trial Summary

This study is an observational study to determine phenotype and genotype of CYP2D6 as predictors of z-endoxifen concentrations in plasma of outgoing patients treated with tamoxifen for at least 4 months

Clinical Trial Description

Tamoxifen is an antiestrogen drug with concentration dependent properties, with z-endoxifen known as active metabolite. Until know therapeutic range for z-endoxifen to improve treatment response was not known. Variation response on tamoxifen can be cause of genetic polymorphism CYP2D6 that can be different between interindividul and ethnic.

The aim of this study is to determine phenotype and genotype of CYP2D6 as predictors of z-endoxifen concentrations in plasma of outgoing patients treated with tamoxifen for at least 4 months ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03504631
Study type Observational
Source Trisakti University
Contact Yenny, MD
Phone +628159661333
Email yenfarmako@gmail.com
Status Recruiting
Phase
Start date October 1, 2017
Completion date December 1, 2018
View Details
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