A Multicentre Retrospective Study on Bicuspid Aortic Valve

Status Recruiting

Clinical Trial Summary

Bicuspid Aortic Valve (BAV) is a common congenital heart disease with an incidence ranging from 0.16% in Asians to 2% in Westerners. Asian populations with BAV have different morphological characteristics from those of the Western populations, and further elucidation of these differences will serve as a guide for the treatment and follow-up of Asian patients. Therefore, we conducted this multicentre retrospective study to analysis the clinical features, long-term development and surgical prognosis of BAV .

Clinical Trial Description

Bicuspid Aortic Valve (BAV) is a common congenital heart disease with an incidence ranging from 0.16% in Asians to 2% in Westerners, and more than one half of patients require medical or surgical treatment within 20 years of diagnosis. Therefore, early diagnosis and effective treatment can help to reduce the incidence of irreversible cardiac impairment and adverse outcomes such as sudden death. Asian populations with BAV have morphological characteristics that differ from those of the Western populations, and further elucidation of these differences could serve as a guide for the treatment and follow-up of Chinese patients. Based on the above background, We conducted this multicentre retrospective study. We will search for patients diagnosed with BAV by echocardiography or other imaging examinations from December 2021 to October 2022 at Nanjing Gulou Hospital, Jiangsu Provincial Hospital and Nanjing Children's Hospital; collect clinical symptoms, signs and examination results of them; find out the specific surgical plan and time of surgery if they have undergone surgery; follow up for symptoms, medication and reexamin Echocardiography to confirm any endpoint events. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05818722
Study type	Observational
Source	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Contact	Jing Yao, Phd
Phone	+8618905188727
Email	w1835199709@163.com
Status	Recruiting
Phase
Start date	December 1, 2022
Completion date	December 1, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT01390181` - The Effect of Losartan in Bicuspid Aortic Valve Patients	N/A
Enrolling by invitation	`NCT06212050` - Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis
Active, not recruiting	`NCT03635424` - Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study	N/A
Recruiting	`NCT06153407` - Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve
Active, not recruiting	`NCT03474159` - Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging	N/A
Not yet recruiting	`NCT06375590` - NavIIcusp: Bicuspid Aortic Valve Stenosis With Navitor Platform International Experience
Recruiting	`NCT05739253` - Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement
Completed	`NCT01823432` - Genetic Risks for Bicuspid Aortic Valve Disease
Completed	`NCT02679261` - Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve	Phase 3
Completed	`NCT01920815` - Bicuspid Valve Aortopathy Feasibility Study
Recruiting	`NCT04817735` - The CASPER Registry	N/A
Recruiting	`NCT02899624` - Whole Exome Sequencing in Bicuspid Aortic Valve Patients	N/A
Recruiting	`NCT05708118` - Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement.
Recruiting	`NCT03495050` - BIVOLUTX: Bicuspid Aortic Stenosis With Evolut Platform International Experience.
Completed	`NCT01760668` - Aortopathy in Persons With Bicuspid Aortic Valve, Turner and Marfan Syndrome	N/A
Not yet recruiting	`NCT05711693` - Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)	N/A
Completed	`NCT05836363` - Fate at Long-term of Mild to Moderate Bicuspid Aortic Valve Disease Left Untreated at the Time of Supracoronary Ascending Aorta Replacement
Completed	`NCT02283970` - Investigation of Patients With BAV Requiring Valve and/or Aortic Repair (GISSI Outliers VAR)
Active, not recruiting	`NCT01026571` - Identification of Genetic Causes of Bicuspid Aortic Valve Disease
Completed	`NCT00412386` - Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve	N/A