Clinical Trials Logo

Clinical Trial Summary

The specific aims of this study are to:

- Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements >40mm.

- Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent.

- In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate


Clinical Trial Description

n/a


Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01390181
Study type Interventional
Source University of Michigan
Contact Nickole L Carlson, BSN
Phone 734 232 4780
Email ngarvey@med.umich.edu
Status Recruiting
Phase N/A
Start date September 2011

See also
  Status Clinical Trial Phase
Recruiting NCT00339053 - Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Phase 4
Not yet recruiting NCT05395598 - Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
Recruiting NCT00549315 - Clinical Study of Thoracic Aortic Aneurysm Exclusion N/A
Recruiting NCT05777460 - Mid- and Long-term Outcomes of Custom-made Aortic Devices
Active, not recruiting NCT05146375 - Genes Modulating the Severity of Aortic Aneurysms (MSF1-TGFBR2)
Completed NCT01082172 - South American Thoracic Stent-Graft Study N/A
Recruiting NCT03824626 - Biomechanical Reappraisal of Planning for Thoracic Endovascular Aortic Repair
Completed NCT04663074 - Intravascular Ultrasound (IVUS) in Complex Aortic Endovascular Interventions
Recruiting NCT04747626 - B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair N/A
Recruiting NCT05143138 - Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used as a Bridging Stent With Branched and Fenestrated Endografts in the Treatment of Aortic Aneurysms Involving the Renal-Mesenteric Arteries
Completed NCT00111176 - STARZ-TX2 Clinical Study: Study of Thoracic Aortic Aneurysm Repair With the Zenith TX2 Endovascular Graft N/A
Recruiting NCT05639400 - Thoraflex Hybrid and Relay Extension Post-Approval Study
Terminated NCT02735720 - The CardiOvascular Remodeling Following Endovascular Aortic Repair (CORE) Study
Completed NCT02256163 - Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm N/A
Recruiting NCT06094127 - Zenith Thoracic Alpha (ZTA) Post-Market Data Collection
Recruiting NCT03998631 - Comparison of Carbon Dioxide and Saline Flush to Saline Flush in TEVAR and TAVI Procedures to Reduce Cerebral Ischemia Phase 1
Completed NCT05414318 - CTAG Dissection/Trauma Post Marketing Surveillance Japan
Completed NCT04756778 - Indexed Aortic Area in Bicuspid Aortic Valve Aortopathy
Withdrawn NCT04197648 - Effects of Exercise on Thoracic Aneurysms N/A
Completed NCT02291718 - Thoracoabdominal Arortic CTA Study Phase 4