Bacterial Infection Clinical Trial
Official title:
Effect of Oral Preparation on Bacterial Colonization of the Pharyngeal Mucosa in Surgery of Head and Neck Cancer
Surgical site infections are an important health indicator for hospitals and a significant
medico-economic issue.
The aim of the study is to assess the impact of chlorhexidine mouthwash performed before
surgery on the bacterial colonization of the pharyngeal mucosa.
The main objective is to reduce the number of patients with significant pathogenic bacterial
colonization for pharyngeal mucosa at the end of the surgery. Oral flora is the same as the
pharyngeal flora, so this suggests that the action of the oral mouthwash may also act in
pharyngeal mucosa by buccopharyngeal communication.
Patients will be randomized into two groups :
- preoperative oral preparation with sodium chloride (NaCl) 0.9% (control group)
- preoperative oral preparation with chlorhexidine (experimental group)
A quantitative and qualitative analysis will be performed from samples collected during the
surgery : before mouthwash (T0), after mouthwash (T1), before intubation in the operating
room (T2), after intubation (T3), before incision (T4) and just before the end of the
intervention on the mucosal scar (T5)
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