Acamprosate in Youth With Fragile X Syndrome

Status Completed

Clinical Trial Summary

Fragile X syndrome (FXS) is the most common inherited form of developmental disability. FXS is inherited from the carrier parent, most often the mothers. FXS is associated with severe interfering behavioral symptoms which include anxiety related symptoms, attention deficit hyperactivity, and aggressive behaviors. Approximately 25-33% of individuals with FXS also meet criteria for autistic disorder. The hypothesis of this study is that treatment with acamprosate will reduce inattention/hyperactivity, language impairment, irritability, social deficits, and cognitive delay in youth with FXS. The purpose of this study is to investigate the effectiveness and tolerability of acamprosate in youth with Fragile X Syndrome and to assess the potential psychophysiological differences between FXS and autism spectrum disorders.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01300923
Study type	Interventional
Source	Indiana University
Contact
Status	Completed
Phase	Phase 2
Start date	August 2010
Completion date	September 2011

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT02625116` - ELENA Cohort: A Long-term Longitudinal Study in a Pediatric Sample With Autism Spectrum Disorders
Not yet recruiting	`NCT06381856` - Improving Participation of Autistic Children and Adolescents in the Habilitation Process
Recruiting	`NCT02280746` - Gluten for Autism Spectrum Disorders	N/A
Completed	`NCT01945957` - Brain Imaging of Intranasal Oxytocin Treatment in Autism	Phase 1
Completed	`NCT01661855` - A Pilot Study of Riluzole Versus Placebo in the Treatment of Children and Adolescents With ASD	Phase 2
Completed	`NCT01780090` - Handheld Technology for Speech Development in Students With Autism	N/A
Completed	`NCT01592747` - Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine	Phase 2
Completed	`NCT01691066` - Pivotal Response Treatment for Infants At-Risk for Autism Spectrum Disorder	N/A
Completed	`NCT01694667` - Omega-3 Fatty Acids for Hyperactivity Treatment in Autism Spectrum Disorder	Phase 2
Active, not recruiting	`NCT01417026` - Intranasal Oxytocin and Learning in Autism	Phase 2
Enrolling by invitation	`NCT01364818` - Brain Connectivity in Neurodevelopmental Disorders in Response to Treatment	N/A
Completed	`NCT01695200` - Omega-3 Fatty Acids in Autism Spectrum Disorders	Phase 4
Completed	`NCT02300597` - Internet-based Support for Young People With ADHD and Autism - a Controlled Study	N/A
Not yet recruiting	`NCT00695812` - The Development of Younger Siblings of Children With Autism Now at 10 Years of Age	N/A
Completed	`NCT01675414` - Understanding Gastrointestinal Conditions in Children With Autism Spectrum Disorder (ASD)	N/A
Recruiting	`NCT05910502` - Project AFECT (Autism Family Empowerment Coaching and Training Program)	N/A
Completed	`NCT02081027` - Pilot Study of Riluzole for Drug-Refractory Irritability in Autism Spectrum Disorders	Early Phase 1
Completed	`NCT02797379` - The Development of a Psychoeducational Tool to Manage Anxiety in People With Autism Spectrum Disorders	N/A
Terminated	`NCT01730079` - Near Infrared Spectroscopy in Children With Autism and ADHD
Completed	`NCT01603225` - Transcranial Direct Current Stimulation and Autism