A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke

Atrial Fibrillation Clinical Trial

— OCEANIC-AF  

Official title:

A Multicenter, International, Randomized, Active Comparator-controlled, Double-blind, Double-dummy, Parallel-group, 2-arm, Phase 3 Study to Compare the Efficacy and Safety of the Oral FXIa Inhibitor Asundexian (BAY 2433334) With Apixaban for the Prevention of Stroke or Systemic Embolism in Male and Female Participants Aged 18 Years and Older With Atrial Fibrillation at Risk for Stroke

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT05643573
• Other study ID #: 19767
• Secondary ID: 2023-503794-38-0
• Status: Terminated
• Phase: Phase 3
• Start date: December 5, 2022
• Est. completion date: January 31, 2024

Study information

• Verified date: February 2024
• Source: Bayer
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Researchers are looking for a better way to treat people with atrial fibrillation and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).

Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.

Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.

The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.

The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.

To see how well the study treatment asundexian works researchers compare:

• how long asundexian works well and

• how long apixaban works well after the start of the treatment. Working well means that the treatments can prevent the following from happening:

• stroke and/or

• systemic embolism. The study will keep collecting data until a certain number of strokes or embolisms happen in the study.

To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person's health.

The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9

• 33 months.

Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.

During the study, the study team will:

• take blood samples

• do physical examinations

• examine heart health using an electrocardiogram (ECG)

• check vital signs such as blood pressure and heart rate

• do pregnancy tests

• ask the participants questions about their quality of life

• ask the participants questions about how they are feeling and what adverse events they are having.

An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 14830
• Est. completion date: January 31, 2024
• Est. primary completion date: January 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years of age or older (at legal age of consent according to local legislation) at the time of signing the informed consent

• Atrial fibrillation documented by ECG evidence with an indication for indefinite treatment with an oral anticoagulant

• CHA2DS2-VASc score = 3 if male or = 4 if female, OR CHA2DS2-VASc score of 2 if male or 3 if female and enrichment criteria.

Exclusion Criteria:

• Mechanical heart valve prosthesis

• Moderate-to-severe mitral stenosis at the time of inclusion into the study

• Atrial fibrillation only due to reversible cause

• Requirement for chronic anticoagulation for a different indication than AF

Related Conditions & MeSH terms

• Atrial Fibrillation
• Embolism
• Stroke

Intervention

Drug:
• Asundexian (BAY2433334)
Once a day
• Apixaban
5 mg or 2.5 mg, twice a day, according to product label.
• Asundexian matching placebo
Placebo to asundexian, once a day
• Apixaban matching placebo
Placebo to apixaban, twice a day

Locations

Country	Name	City	State
Argentina	Instituto de Investigaciones Clinicas Bahia Blanca	Bahía Blanca	Buenos Aires
Argentina	Centro de Investigaciones Metabólicas	Buenos Aires	Ciudad Auton. De Buenos Aires
Argentina	Centro de Investigaciones Clínicas	Caba	Ciudad Auton. De Buenos Aires
Argentina	Inst. de Cardiología de Corrientes Juana Francisca Cabral	Corrientes
Argentina	Centro de Investigación y Prevención Cardiovascular	General Arenales	Buenos Aires
Argentina	Hospital Italiano de La Plata | Clinical Research Department	La Plata	Buenos Aires
Argentina	Centro de Investigaciones Medicas Lanus | Research Department	Lanus	Buenos Aires
Argentina	Instituto de Investigaciones Clínicas	Mar del Plata	Buenos Aires
Argentina	Instituto Médico de la Fundación Estudios Clinicos	Rosario	Santa Fe
Argentina	Laboratorio de Hemostasia y Trombosis	Rosario	Santa Fe
Argentina	CardioAlem Investigaciones Monitoreos San Isidro SRL	San Isidro	Buenos Aires
Argentina	Investigaciones Clinicas Tucuman | San Miguel de Tucuman, Argentina	San Miguel de Tucumán	Tucuman
Argentina	Instituto de Investigaciones Clínicas San Nicolás	San Nicolás	Buenos Aires
Argentina	Centro de Investigaciones Clinicas del Litoral	Santa Fe
Argentina	Centro de Investigaciones Medicas Temperley	Temperley	Buenos Aires
Argentina	Centro de Especialidades Médicas	Villa Luro	Ciudad Auton. De Buenos Aires
Argentina	Instituto de Investigaciones Clínicas Zárate	Zárate	Buenos Aires
Australia	Flinders Medical Centre	Adelaide	South Australia
Australia	Nightingale Research	Adelaide	South Australia
Australia	Royal Adelaide Hospital	Adelaide	South Australia
Australia	Advara HealthCare Wesley	Auchenflower	Queensland
Australia	Grampians Health Ballarat	Ballarat	Victoria
Australia	Sunshine Coast University Hospital	Birtinya	Queensland
Australia	Blacktown Hospital	Blacktownn	New South Wales
Australia	Eastern Health	Box Hill	Victoria
Australia	Royal Brisbane & Women's Hospital	Brisbane	Queensland
Australia	Concord Repatriation General Hospital	Concord	New South Wales
Australia	The Canberra Hospital	Garran	Australian Capital Territory
Australia	Barwon Health	Geelong	Victoria
Australia	The Prince Charles Hospital	Herston	Queensland
Australia	Baker Heart and Diabetes Institute	Hoppers Crossing	Victoria
Australia	Nepean Hospital	Kingswood
Australia	Advara HealthCare Leabrook	Leabrook	South Australia
Australia	South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department	Liverpool	New South Wales
Australia	Cabrini Malvern	Malvern	Victoria
Australia	Core Research Group Pty Ltd | Brisbane, Australia	Milton	Queensland
Australia	Fiona Stanley Hospital	Murdoch	Western Australia
Australia	John Hunter Hospital	New Lambton	New South Wales
Australia	Royal Melbourne Hospital	Parkville	Victoria
Australia	Advara HealthCare Joondalup	Perth	Western Australia
Australia	The Alfred Hospital	Prahran	Victoria
Australia	Redcliffe District Hospital	Redcliffe	Queensland
Australia	Gold Coast University Hospital	Southport	Queensland
Australia	The Avenue Cardiovascular Centre	St Kilda East	Victoria
Australia	Illawarra Shoalhaven Local Health District	Wollongong	New South Wales
Australia	Queen Elizabeth Hospital AUS	Woodville South	South Australia
Austria	Krankenhaus St. Josef Braunau | Innere Medizin I	Braunau	Oberösterreich
Austria	LKH Feldkirch | Innere Medizin I mit Kardiologie	Feldkirch	Vorarlberg
Austria	MedUni Graz | Kardiologie	Graz	Steiermark
Austria	Landeskrankenhaus Hall | Abteilung fuer Innere Medizin	Hall in Tirol	Tirol
Austria	MedUni Innsbruck | Kardiologie und Angiologie	Innsbruck	Tirol
Austria	Klinikum Klagenfurt | Innere Medizin und Kardiologie	Klagenfurt	Kärnten
Austria	Elisabethinen Linz | Kardiologie, Angiologie & Intensiv Med	Linz	Oberösterreich
Austria	Kepler UK Linz | Kardiologie & Intensivmedizin Campus III	Linz	Oberösterreich
Austria	Landesklinikum Mistelbach|Kardiologie u. Internistische Med	Mistelbach	Niederösterreich
Austria	Uniklinikum Salzburg|Innere Medizin II, Kardiologie	Salzburg
Austria	UK St. Poelten | Innere Med III	St. Poelten	Niederösterreich
Austria	Klinik Floridsdorf | Herz-, Gefaess- u. Kardio Ambulaz	Vienna	Wien
Austria	MedUni Wien | Innere Medizin II, Kardiologie	Vienna	Wien
Austria	Klinikum Wels-Grieskirchen | Innere Medizin II	Wels	Oberösterreich
Austria	Hanusch Krankenhaus | 2. Medizinische Abteilung	Wien
Austria	Imed19-privat	Wien
Belgium	Algemeen Stedelijk Ziekenhuis Campus Aalst	Aalst
Belgium	OL Vrouwziekenhuis - Campus Aalst	Aalst
Belgium	ZNA Middelheim	Antwerp
Belgium	Imeldaziekenhuis - St-Elisabethkliniek / Cardiology	Bonheiden	Antwerpen
Belgium	Algemeen Ziekenhuis Klina | Cardiology Department	Brasschaat
Belgium	AZ Sint-Jan Brugge-Oostende | Sint-Jan - Cardiology	Brugge
Belgium	CU Saint-Luc/UZ St-Luc	Bruxelles - Brussel
Belgium	AZ Sint Blasius, Cardiology, Dendermonde	Dendermonde
Belgium	UZ Antwerpen - Cardiology	Edegem	Antwerpen
Belgium	Ziekenhuis Oost-Limburg | Genk, Sint-Jan campus - Cardiology Department	Genk
Belgium	AZ St-Lucas Campus St-Lucas - Cardiology	Gent	Oost-Vlaanderen
Belgium	Maria Middelares General Hospital | Cardiology Department	Gent	Oost-Vlaanderen
Belgium	Grand Hôpital de Charleroi	Gilly
Belgium	Jessa Ziekenhuis	Hasselt
Belgium	AZ Groeninge Campus Kennedylaan - Cardiology	Kortrijk	West-Vlaanderen
Belgium	UZ Leuven Gasthuisberg	Leuven	Vlaams Brabant
Belgium	CHR de la Citadelle - Cardiology	Liege
Belgium	CHC MontLégia Neurology Department	Liège
Belgium	AZ Sint-Maarten	Mechelen
Belgium	AZ Delta / Cardiology	Roeselare
Belgium	Vitaz Sint-Niklaas Moerland	Sint-Niklaas
Belgium	GZA Ziekenhuizen | Saint Augustine Campus - Cardiology Department	Wilrijk	Antwerpen
Belgium	University Hospital Louvain Namur | Godinne - Cardiology Department	Yvoir	Namur
Brazil	Clínica do Coração	Aracaju	Sergipe
Brazil	Cardresearch Cardilogia Assistencial e de Pesquisas LTDA	Belo Horizonte	Minas Gerais
Brazil	Clínica Procardio Ltda	Blumenau	Santa Catarina
Brazil	UPECLIN - Unidade de Pesquisa Clínica de Botucatu	Botucatu	Sao Paulo
Brazil	Inst. Pesq. Clínica de Campinas - Saraiva & Berlinger	Campinas	Sao Paulo
Brazil	Centro de Pesquisa de São Francisco	Curitiba	Parana
Brazil	Hospital Universitário Evangélico de Curitiba	Curitiba	Parana
Brazil	QUANTA Diagnósticos e Terapia	Curitiba	Parana
Brazil	Hospital das Clínicas de Goiânia	Goiânia	Goiás
Brazil	ICM - Instituto do Coração de Marília	Marília	Sao Paulo
Brazil	Eurolatino Pesquisas Médicas Ltda.	Minas Gerais
Brazil	Núcleo de Pesquisa Clínica do Hospital Angelina Caron	Paraná	Parana
Brazil	Hospital Maternidade e Pronto Socorro Santa Lucia	Poços de Caldas	Minas Gerais
Brazil	Hospital de Clínicas de Porto Alegre	Porto Alegre	Rio Grande Do Sul
Brazil	Hospital Nossa Senhora da Conceição	Porto Alegre	Rio Grande Do Sul
Brazil	Irmandade Santa Casa de Misericordia de Porto Alegre	Porto Alegre	Rio Grande Do Sul
Brazil	Hospital São Lucas - Rio de Janeiro	Rio de Janeiro
Brazil	Instituto Cardio Pulmonar da Bahia	Salvador	Bahia
Brazil	Hospital e Maternidade Dr Christóvão da Gama	Santo André	Sao Paulo
Brazil	Hospital de Base | Integrated Research Center	São José do Rio Preto	Sao Paulo
Brazil	Hospital Alemao Oswaldo Cruz	Sao Paulo
Brazil	Hospital Samaritano Paulista	São Paulo	Sao Paulo
Brazil	Instituto Dante Pazzanese de Cardiologia	São Paulo	Sao Paulo
Brazil	Irmandade da Santa Casa de Misericordia - Sao Paulo	São Paulo	Sao Paulo
Brazil	PUC Campinas	São Paulo	Sao Paulo
Bulgaria	Multiprofile Hospital for Active Treatment Puls | Clinical Trial Center	Blagoevgrad
Bulgaria	MHAT '' Heart and Brain'' Burgas	Burgas
Bulgaria	MC Avitsena EOOD	Kardzhali
Bulgaria	¿ultidisc. hosp. for act. treatm. Sveti Georgi - Pernik OOD	Pernik
Bulgaria	Medical centre Hipokrat - N EOOD	Plovdiv
Bulgaria	Multiprofile Hospital for Active Treatment Medline Clinic	Plovdiv
Bulgaria	Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department	Plovdiv
Bulgaria	Medical Center Rusemed	Ruse
Bulgaria	MHAT Shumen AD	Shumen
Bulgaria	Multiprofile Hospital for Active Treatment - Silistra	Silistra
Bulgaria	Diagnostic-Consultative Center XX | Cardiology Department	Sofia
Bulgaria	FutureMeds | Diagnostic Consultative Center Ascendent	Sofia
Bulgaria	Medical Center Cardiohelp	Sofia
Bulgaria	Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department	Sofia
Bulgaria	Multiprofile Hospital for Active Treatment National Cardiology Hospital | Cardiology Department	Sofia
Bulgaria	Multiprofile Hospital for Active Treatment Sveta Sofia	Sofia
Bulgaria	Second Medical Center Sofia EOOD	Sofia
Bulgaria	Umhatem N. I. Pirogov EAD / Cardiology	Sofia
Bulgaria	University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Cardiology Clinic	Sofia
Bulgaria	Medical Center Zara-Med EOOD | Cardiology Department	Stara Zagora
Bulgaria	Multiprofile Hospital for Active Treatment Trakiya Park | Cardiology Department	Stara Zagora
Bulgaria	NOVA Clinic Medical Center | Varna, BG	Varna
Bulgaria	MHAT Dr Stefan Cherkezov	Veliko Tarnovo
Canada	Viacar Recherches Cliniques Inc.	Brossard	Quebec
Canada	Cambridge Cardiac Care Center	Cambridge	Ontario
Canada	CIUSSS Saguenay Lac-St-Jean	Chicoutimi	Quebec
Canada	Edmonton Cardiology Consultants	Edmonton	Alberta
Canada	University of Alberta Hospital	Edmonton	Alberta
Canada	QEII Health Sciences Centre	Halifax	Nova Scotia
Canada	Hamilton Health Sciences	Hamilton	Ontario
Canada	Hamilton Med.Research Group - DCT	Hamilton	Ontario
Canada	Hamilton Medical Research Group	Hamilton	Ontario
Canada	McMaster University Medical Centre	Hamilton	Ontario
Canada	Interior Health - Royal Inland Hospital	Kamloops,	British Columbia
Canada	Centre intégré de santé et de services sociaux de Laval, Hôp	Laval	Quebec
Canada	London Health Sciences Centre | University Hospital - London Heart Rhythm Program - Cardiology	London	Ontario
Canada	Milestone Research	London	Ontario
Canada	Centricity Research Mirabel Multispecialty	Mirabel	Quebec
Canada	G.A. Research Associates, Ltd.	Moncton	New Brunswick
Canada	CHUM - Centre hospitalier de l'Université de Montréal	Montreal	Quebec
Canada	CIUSSS NÎM Hôpital Sacré-Coeur	Montreal	Quebec
Canada	McGill University Health Centre - Glen Site	Montreal	Quebec
Canada	Montreal Heart Institute	Montréal,	Quebec
Canada	Fraser Clinical Trials, Inc.	New Westminster	British Columbia
Canada	Oakville Cardiovascular Research	Oakville	Ontario
Canada	Dr. James Cha	Oshawa	Ontario
Canada	Kawartha Cardiology Clinical Trials	Peterborough	Ontario
Canada	CHU de Québec-Université Laval	Quebec
Canada	Institut universitaire de cardiologie et de pneumologie de Q	Québec	Quebec
Canada	Heart Health Institute	Scarborough	Ontario
Canada	CIUSSS de l'Estrie-CHUS, Hopital Fleurimont	Sherbrooke	Quebec
Canada	Niagara Health - St. Catharines Site	St. Catharines	Ontario
Canada	Memorial University of Newfoundland	St. John's	Newfoundland and Labrador
Canada	CISSSL - Hopital Pierre-Le Gardeur	Terrebonne	Quebec
Canada	Sunnybrook Health Sciences Centre	Toronto	Ontario
Canada	Toronto General Hospital UHN	Toronto	Ontario
Canada	Unity Health Toronto: St. Michael's Hospital	Toronto	Ontario
Canada	Women's College Hospital | WCH Main Site - Women's College Research Institute - Cardiology Department	Toronto	Ontario
Canada	Diex Research Trois-Rivières Inc.	Trois-Rivieres	Quebec
Canada	Vancouver General Hospital	Vancouver	British Columbia
Canada	Victoria Heart Institute Foundation	Victoria	British Columbia
Canada	Dr. Louis Yao	York	Ontario
China	Baotou Central Hospital	Baotou	Inner Mongolia
China	The First Affiliated Hospital of Baotou Medical College	Baotou	Inner Mongolia
China	Beijing Anzhen Hospital, Capital Medical University	Beijing
China	Beijing Chaoyang Hospital, Capital Medical University	Beijing
China	Beijing Tongren Hospital, Capital Medical University (West)	Beijing
China	Beijing Tsinghua Changgung Hospital	Beijing
China	China-Japan Friendship Hospital	Beijing
China	Peking Union Medical College Hospital CAMS	Beijing
China	Peking University First Hospital	Beijing
China	Xuanwu Hospital Capital Medical University	Beijing
China	Cangzhou Central Hospital	Cangzhou	Hebei
China	China-Japan Union Hospital of Jilin University	Changchun	Jilin
China	The Third Hospital of Changsha	Changsha	Hunan
China	The Third Xiangya Hospital of Central South University	Changsha	Hunan
China	Chengdu Second People's Hospital	Chengdu	Sichuan
China	SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos	Chengdu	Sichuan
China	West China Hospital,Sichuan University	Chengdu	Sichuan
China	Daqing Oilfield General Hospital	Daqing	Heilongjiang
China	People's Hospital of Deyang City	Deyang	Sichuan
China	The 1st Affiliated Hospital Fujian Medical University	Fuzhou	Fujian
China	Guangdong Provincial People's Hospital	Guangzhou	Guangdong
China	Guangzhou First People Hospital	Guangzhou	Guangdong
China	Guangzhou Panyu Central Hospital	Guangzhou	Guangdong
China	The 2nd Affiliated Hospital of Guangzhou Medical University	Guangzhou	Guangdong
China	The First Affiliated Hospital of Guangzhou University of TCM	Guangzhou	Guangdong
China	The First Affiliated Hospital of Jinan University	Guangzhou	Guangdong
China	Hainan Provincial People's Hospital	Haikou	Hainan
China	Affiliated Hangzhou First People's Hospital, Zhejiang Univ	Hangzhou	Zhejiang
China	The 1st Affiliated Hospital of Zhejiang University	Hangzhou	Zhejiang
China	The 4th Affiliated Hospital of Harbin Medical University	Harbin	Heilongjiang
China	The First Affiliated Hospital of Harbin Medical University	Harbin	Heilongjiang
China	Inner Mongolia People's Hospital	Hohhot	Inner Mongolia
China	Huai'an First People's Hospital, Nanjing Medical University	Huai'An	Jiangsu
China	Huizhou Central People's Hospital	Huizhou	Guangdong
China	Affiliated Hospital of Jiangsu University	JiangSu	Jiangsu
China	Jinan Central Hospital	Jinan	Shandong
China	Qilu Hospital of Shandong University	Jinan	Shandong
China	The Second Hospital of Shandong University	Jinan	Shandong
China	Affiliated Hospital of Jining Medical University	Jining	Shandong
China	Jining No.1 People's Hospital	Jining	Shandong
China	The First Affiliated Hospital of Jinzhou Medical University	Jinzhou	Liaoning
China	Lanzhou University Second Hospital	Lanzhou	Gansu
China	Liuzhou Worker's Hospital	Liuzhou	Guangxi
China	1st Affiliated Hospital of Henan Science and Technology Univ	Luoyang	Henan
China	Luoyang Third People's Hospital	Luoyang	Henan
China	Jiangxi Provincial People's Hospital	Nanchang	Jiangxi
China	The First Affiliated Hospital of NanChang University	Nanchang	Jiangxi
China	The Third Hospital of Nanchang	Nanchang	Jiangxi
China	Nanjing First Hospital	Nanjing	Jiangsu
China	Nanjing Jiangning Hospital	Nanjing	Jiangsu
China	The Second Affiliated Hospital of Nanjing Medical university	Nanjing	Jiangsu
China	Zhongda Hospital Southeast University	Nanjing	Jiangsu
China	Hwa Mei Hospital, University of Chinese Academy Sciences	Ningbo	Zhejiang
China	Ningbo First Hospital	Ningbo	Zhejiang
China	Panjin Liaohe Oilfield Gem Flower Hospital	Panjin	Liaoning
China	PingXiang People's Hospital	Pingxiang	Jiangxi
China	Hainan Third People's Hospital (Province Nongken Sanya Hopt)	Sanya	Hainan
China	Huashan Hospital, Fudan University	Shanghai
China	Shanghai General Hospital	Shanghai
China	Shanghai Putuo District Central Hospital	Shanghai
China	Zhongshan Hospital, Fudan University	Shanghai
China	The First Hospital of Hebei Medical Univesity	Shijiazhuang	Hebei
China	Taian City Central Hospital	Taian	Shandong
China	Shanxi Bethune Hospital	Taiyuan	Shanxi
China	Shanxi Candiovascular Hospital	Taiyuan	Shanxi
China	Taizhou Hospital of Zhejiang Province	Taizhou	Zhejiang
China	Taizhou People's Hospital	Taizhou	Jiangsu
China	Teda International Cardiovascular Hospital	Tianjin
China	Tianjin People's Hospital	Tianjin
China	Tonghua Central Hospital	Tonghua	Jilin
China	The First Affiliated Hospital of Xinjiang Medical University	Urumchi	Xinjiang
China	The First Affiliated Hospital of Wenzhou Medical University	Wenzhou	Zhejiang
China	Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech	Wudan	Hubei
China	Renmin Hospital of Wuhan University	Wuhan	Hubei
China	The Central Hospital of Wuhan, Tongji Medl Collg Huazhong...	Wuhan	Hubei
China	Wuhan No. 4 Hospital	Wuhan	Hubei
China	Shaanxi Provincial People's Hospital	Xi'an	Shanxi
China	Xiamen Cardiovascular Hospital Xiamen University	Xiamen	Fujian
China	Yan'an University Xianyang Hospital	Xianyang	Shaanxi
China	Qinghai University Affiliated Hospital	Xining	Qinghai
China	Xinxiang Central Hospital	Xinxiang	Henan
China	Northern Jiangsu People's Hospital	Yangzhou	Jiangsu
China	Yangzhou No. 1 People's Hospital (West Hospital)	Yangzhou	Jiangsu
China	General Hospital of Ningxia Medical University	Yinchuan	Ningxia
China	The First People's Hospital of Yinchuan	Yinchuan	Ningxia
China	Yuncheng Central Hospital	Yuncheng	Shanxi
China	The First affiliated Hospital of Hebei North University	Zhangjiakou	Hebei
China	Zibo Central Hospital	Zibo	Shandong
Czechia	Amkardia s.r.o.	Brno
Czechia	Fakultni nemocnice Brno	Brno
Czechia	Kardiologicka ambulance Brno s.r.o.	Brno
Czechia	Vojenska nemocnice Brno	Brno
Czechia	Kardiologicka ambulance Cormedico	Bruntal
Czechia	Nemocnice Ceske Budejovice, a.s. Department of kardiologie	Ceske Budejovice
Czechia	Mrozek kardiologie	Frydek-Mistek
Czechia	MATMED s.r.o.	Hodonin
Czechia	Krajska Nemocnice Liberec	Liberec
Czechia	Fakultni Nemocnice Olomouc	Olomouc
Czechia	Benedor s.r.o.	Ostrava - Poruba
Czechia	MUDr. Michalik s.r.o.	Ostrava-Zabreh
Czechia	Fakultni nemocnice Plzen	Plzen
Czechia	Cevni Kulatak	Praha
Czechia	Fakultni nemocnice Kralovske Vinohrady	Praha 10
Czechia	Institut Klinicke a Experimentalni Mediciny	Praha 4
Czechia	Fakultni nemocnice v Motole	Praha 5
Czechia	Medicon Poliklinika Holesovice	Praha 7
Czechia	Nemocnice Slany	Slany
Czechia	Cardio Research s.r.o.	Zlin
Denmark	Region Nordjylland | Aalborg University Hospital - Cardiology Department	Aalborg
Denmark	Region Midtjylland | Aarhus University Hospital - Heart Diseases - Clinical Research	Århus N
Denmark	Capital Region | Amager Hospital - Cardiology Outpatient Clinic	Copenhagen
Denmark	Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed	Esbjerg
Denmark	Capital Region | Frederiksberg Hospital - Department of Cardiology Research	Frederiksberg
Denmark	Capital Region | Gentofte Hospital - Cardiology Research	Hellerup
Denmark	Capital Region | Herlev Hospital - Department of Heart Disease	Herlev
Denmark	Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research	Herning
Denmark	Nordsjaellands Hospital | Hillerod - Cardiology Department	Hilleroed
Denmark	Region Nordjylland | Hjoerring - Cardiology Department	Hjørring
Denmark	Holbæk Sygehus	Holbæk
Denmark	Capital Region | Hvidovre Hospital - Department of Cardiology	Hvidovre
Denmark	Sygehus Lillebaelt | Kolding Sygehus - Medicinske Sygdomme	Kolding
Denmark	Sjællands Universitetshospital Roskilde	Roskilde
Denmark	Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit	Svendborg
Denmark	Region Midtjylland | Viborg Regional Hospital - Cardiology - Heart Research	Viborg
Estonia	Dr Signe Alliksoo Family Doctors Practice	Tallinn
Estonia	East Tallinn Central Hospital	Tallinn
Estonia	North Estonia Medical Centre Foundation	Tallinn
Estonia	Office of Arvo Rosenthal	Tallinn
Estonia	Pirita Family Doctors Centre	Tallinn
Estonia	West Tallinn Central hospital	Tallinn
Estonia	Tartu University Hospital	Tartu
Finland	HUS Jorvin sairaala	Espoo
Finland	StudyCor Oy	Jyväskylä
Finland	Health Step Finland Oy	Kuopio
Finland	Kuopion yliopistollinen sairaala	Kuopio
Finland	Oulun yliopistollinen sairaala	Oulu
Finland	Tays Sydänsairaala	Tampere
Finland	Turun yliopistollinen keskussairaala	Turku
France	Centre Hospitalier Universitaire - Angers	Angers
France	Centre Hospitalier Intercommunal de la Côte Basque-Bayonne	Bayonne
France	Hopital Charles Nicolle Chu Rouen	Bois-Guillaume
France	Hôpital La Cavale Blanche - CHU de Brest	Brest
France	Hôpital Louis Pradel - Bron	Bron
France	CHU de Caen - Hôpital Côte de Nacre	CAEN cedex 9
France	Hôpital Trousseau - Tours	Chambray-lès-Tours
France	Centre Hospitalier - Cholet	Cholet
France	Hôpital Henri Mondor	Creteil
France	CHU GRENOBLE - Hopital Michallon	GRENOBLE Cedex 09
France	Centre Hospitalier Départemental Vendée	LA ROCHE SUR YON cedex
France	Centre Hospitalier Louis Pasteur	Le Coudray
France	Centre Hospitalier du Docteur Schnaffer - Lens	Lens
France	Hôpital Dupuytren	Limoges Cedex
France	Hôpital Guillaume et René Laennec - Nantes	Nantes
France	Nouvelles Cliniques Nantaises - Nantes	NANTES cedex 2
France	Hôpital Pasteur - Nice	Nice
France	Hopital Carémeau - Nîmes	Nîmes
France	Hôpital de la Pitié-Salpétrière	Paris
France	Institut Mutualiste Montsouris	Paris
France	Hopital Européen Georges Pompidou - Paris	Paris Cedex 15
France	Hôpital Cardiologique - Pessac	Pessac
France	CHU Rennes, H Pontchaillou, Cardiologie	Rennes
France	Centre Hospitalier Régional - Saint Brieuc	Saint Brieuc
France	Hôpital Civil - Strasbourg	Strasbourg
France	CHI Toulon - H La Seyne - Cardiologie	Toulon
France	Clinique Pasteur - Toulouse	Toulouse
France	Hôpital de Rangueil - Toulouse	TOULOUSE cedex
France	Centre Hospitalier Gustave Dron - Tourcoing	Tourcoing
France	Centre Hospitalier - Valenciennes Cedex	Valenciennes
France	Centre Hospitalier Universitaire de Nancy	Vandoeuvre-les-nancy
Germany	UniKlinikum Aachen|Kardio, Angio, Intensivmedizin	Aachen	Nordrhein-Westfalen
Germany	Universitaets Herzzentrum Bad Krozingen	Bad Krozingen	Baden-Württemberg
Germany	St.Johannes-Hospital|Klinik fuer Innere Medizin I	Dortmund	Nordrhein-Westfalen
Germany	Krankenhaus Dresden-Friedrichstadt	Dresden	Sachsen
Germany	Pratia | Klinische Forschung Dresden	Dresden	Sachsen
Germany	Zentrum für klinische Prüfungen	Dresden	Sachsen
Germany	Ev. Krankenhaus Hagen-Haspe|Kardiologie und Rhythmologie	Hagen	Nordrhein-Westfalen
Germany	Cardiologicum Hamburg	Hamburg
Germany	Klinische Forschung Hamburg GmbH	Hamburg
Germany	Uniklinikum Hamburg-Eppendorf|Klinik für Kardiologie	Hamburg
Germany	Medizinische Hochschule Hannover|Kardiologie und Angiologie	Hannover	Niedersachsen
Germany	Uni-Klinikum Heidelberg | Kardiologie Angiologie Pneumologie	Heidelberg	Baden-Württemberg
Germany	Uniklinik Jena / Kardiologie	Jena	Thüringen
Germany	St. Vinzenz-Hospital|Innere Medizin III, Kardiologie	Koeln	Nordrhein-Westfalen
Germany	MEDICLIN Herzzentrum Lahr|Kardiologie	Lahr	Baden-Württemberg
Germany	Uniklinik Leipzig / Kardiologie	Leipzig	Sachsen
Germany	Klinikum Lüdenscheid - Märkische Kliniken GmbH	Lüdenscheid	Nordrhein-Westfalen
Germany	Cardio Centrum Ludwigsburg	Ludwigsburg	Baden-Württemberg
Germany	Universitätsmedizin der Johannes Gutenberg Universität Mainz	Mainz	Rheinland-Pfalz
Germany	Praxis Hr. Dr. med. Jens Taggeselle	Markkleeberg	Sachsen
Germany	Kliniken Maria Hilf GmbH	Mönchengladbach	Nordrhein-Westfalen
Germany	Sana-Klinikum Remscheid|Kardio, Angio, Pneumo u. Intensivmed	Remscheid	Nordrhein-Westfalen
Germany	Hegau-Bodensee-Klinikum Singen|I. Medizinische Klinik	Singen	Baden-Württemberg
Germany	Siteworks Pruefzentrum Voelklingen	Voelklingen	Saarland
Germany	Josephs-Hospital|Kardiologie, Rhythmologie und Angiologie	Warendorf	Nordrhein-Westfalen
Germany	Kardiologische Praxis Hr. Dr. A. Al-Zoebi	Wermsdorf	Sachsen
Germany	Forschungszentrum Ruhr KliFoCenter GmbH	Witten	Nordrhein-Westfalen
Germany	Klinikum Worms gGmbH|Kardiologie und Angiologie	Worms	Rheinland-Pfalz
Greece	University General Hospital of Alexandroupolis	Alexandroupoli
Greece	EVANGELISMOS General Hospital of Athens	Athens
Greece	G. GENNIMATAS General State Hospital of Athens	Athens
Greece	General Hospital of Athens "ALEXANDRA"	Athens
Greece	HIPPOKRATION General Hospital of Athens	Athens
Greece	LAIKO General Hospital of Athens	Athens
Greece	Naval Hospital of Athens	Athens
Greece	University General Hospital ATTIKON	Chaidari
Greece	Thriassio General Hospital of Elefsina	Elefsina
Greece	University General Hospital of Heraklion	Heraklion
Greece	Ioannina University General Hospital	Ioannina
Greece	KAT General Hospital of Athens	Kifisia / Athens	Attica
Greece	Univ. General Hospital of Larissa	Larissa
Greece	University General Hospital of Larissa	Larissa
Greece	MITERA Hospital	Maroussi
Greece	Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA	Nea Ionia / Athens
Greece	University General Hospital of Patra	Patra
Greece	AHEPA University General Hospital of Thessaloniki	Thessaloniki
Greece	Hippokration General Hospital of Thessaloniki	Thessaloniki
Greece	General Hospital ASKLEPIEIO VOULAS	Voula
Hungary	Cardiomobile Egeszsegugyi Szolgaltato Kft.	Balatonfured
Hungary	Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet	Budapest
Hungary	Budapesti Uzsoki Utcai Korhaz	Budapest
Hungary	Semmelweis University	Budapest
Hungary	Belinus Bt.	Debrecen
Hungary	Kardio Egeszseghaz - Dr Amer Sayour Egyeni Vallakozo	Gyor
Hungary	Trial Pharma Kft. Gyula	Gyula
Hungary	Somogy Varmegyei Kaposi Mor Oktato Korhaz	Kaposvar
Hungary	Komaromi Selye Janos Korhaz	Komarom
Hungary	Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz	Miskolc
Hungary	TaNa Med Kft.	Mosonmagyarovar
Hungary	Kanizsai Dorottya Hospital	Nagykanizsa
Hungary	Borbanya Praxis Bt.	Nyiregyhaza
Hungary	Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.	Nyiregyhaza
Hungary	Dr. Nagy Laszlo Egyeni Egeszsegugyi Vallalkozo	Oroshaza
Hungary	Oroshaza Hospital	Oroshaza
Hungary	Coromed Smo Kft	Pecs
Hungary	Pecsi Tudomanyegyetem Klinikai Kozpont	Pecs
Hungary	Complex Rendelo Med Zrt.	Szekesfehervar
Hungary	Tolna Varmegyei Balassa Janos Korhaz	Szekszard
Hungary	Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz	Szombathely
Hungary	Belvarosi Egeszseghaz Kft.	Zalaegerszeg
India	The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital)	Calcutta
India	Asian Institute of Gastroenterology (AIG Hospital)	Hyderabad
India	Lisie Hospital	Kochi	Kerala
India	Vijan Cardiac & Critical Care Centre	Nashik	Maharashtra
India	All India Institute of Medical Sciences (AIIMS) - New Delhi	New Delhi
India	Sir Gangaram Hospital, Delhi	New Delhi
India	Vardhman Mahavir Medical College & Safdarjung Hospital (VMMC-SJH)	New Delhi
India	King Edward Memorial (KEM) Hospital - Pune	Pune
India	Shri B.D. Mehta Mahavir Heart Institute	Surat
Israel	Clalit Health Services through HaEmek Medical Center	Afula
Israel	Assuta Ashdod	Ashdod
Israel	Barzilai Ashkelon University Medical Center | Cardiology Department	Ashkelon
Israel	Assuta Beer Sheva	Beer Sheva
Israel	Soroka University Medical Center	Beer Sheva
Israel	Hillel Yaffe Medical Center	Hadera
Israel	Bnai Zion Medical Center	Haifa
Israel	Lady Davis Carmel Medical Center	Haifa
Israel	Rambam Health Corporation	Haifa
Israel	Edith Wolfson Medical Center	Holon
Israel	Hadassah Hebrew University Hospital Ein Kerem	Jerusalem
Israel	Shaare Zedek Medical Center	Jerusalem
Israel	Meir Medical Center	Kfar Saba
Israel	Poriya Medical Center | Cardiology Department	Lower Galilee
Israel	Health Corporation of Galilee Medical Center	Nahariya
Israel	Clalit Health Services Rabin Medical Center-Beilinson Campus	Petach Tikva
Israel	Clalit Health Services Rabin Medical Center-Beilinson Campus	Petah Tikva
Israel	Chaim Sheba Medical Center	Ramat Gan
Israel	Kaplan Medical Center	Rehovot
Israel	Tel-Aviv Sourasky Medical Center	Tel Aviv
Israel	Health Corporation of the Ziv Medical Center (R.A.)	Zefat
Israel	Shamir Medical Center (Assaf Harofeh)	Zrifin
Italy	A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"	Ancona	Marche
Italy	AUSL Toscana Sud-Est	Arezzo	Toscana
Italy	ASUR Marche - Area Vasta 5	Ascoli Piceno	Marche
Italy	Ente Ecclesiastico Ospedale Generale Regionale Miulli	Bari	Puglia
Italy	ASST Papa Giovanni XXIII	Bergamo	Lombardia
Italy	AUSL di Bologna	Bologna	Emilia-Romagna
Italy	ASST del Garda	Brescia	Lombardia
Italy	A.O Sant'Anna-San Sebastiano	Caserta	Campania
Italy	ASL2 Lanciano-Vasto-Chieti	Chieti	Abruzzo
Italy	A.O.U. di Ferrara	Ferrara	Emilia-Romagna
Italy	A.O.U. Careggi	Firenze	Toscana
Italy	A.O.U. Ospedali Riuniti Foggia	Foggia	Puglia
Italy	IRCCS Centro Cardiologico Monzino S.p.A	Milano	Lombardia
Italy	Istituto Clinico Humanitas - Humanitas Mirasole S.p.A.	Milano	Lombardia
Italy	A.O.U. di Modena - Policlinico	Modena	Emilia-Romagna
Italy	A.O.R.N. Ospedali dei Colli (Monaldi-Cotugno-CTO)	Napoli	Campania
Italy	A.O.U. Policlinico Federico II Napoli	Napoli	Campania
Italy	A.O.U. Maggiore della Carità	Novara	Piemonte
Italy	A.O.U. di Padova	Padova	Veneto
Italy	A.O.U. di Parma	Parma	Emilia-Romagna
Italy	A.O. di Perugia	Perugia	Umbria
Italy	A.O.U. Pisana	Pisa	Toscana
Italy	A.O.U. Policlinico Umberto I	Roma	Lazio
Italy	Asl Roma 2	Roma	Lazio
Italy	ULSS2 Marca Trevigiana	Treviso	Veneto
Italy	ASST Sette Laghi	Varese	Lombardia
Italy	ULSS3 Serenissima	Venezia	Veneto
Japan	Ageo Central General Hospital	Ageo	Saitama
Japan	Akashi Medical Center	Akashi	Hyogo
Japan	Mazda Hospital of Mazda Motor Corporation	Aki-gun	Hiroshima
Japan	Hyogo Prefectural Amagasaki General Medical Center	Amagasaki	Hyogo
Japan	Asahikawa City Hospital	Asahikawa	Hokkaido
Japan	Japan Red Cross Society Azumino Hospital	Azumino	Nagano
Japan	Tokyo Medical and Dental University Hospital	Bunkyo-ku	Tokyo
Japan	Tokyo-Eki Center-building Clinic	Chuo-ku	Tokyo
Japan	Fujisawa City Hospital	Fujisawa	Kanagawa
Japan	Fukui General Clinic	Fukui
Japan	Fukui Prefectural Hospital	Fukui
Japan	Fukuoka University Hospital	Fukuoka
Japan	Fukuoka University Nishijin Hospital	Fukuoka
Japan	Kyushu Central Hospital	Fukuoka
Japan	Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital	Fukuoka
Japan	Munakata Suikokai General Hospital	Fukutsu	Fukuoka
Japan	Chiba Tokushukai Hospital	Funabashi	Chiba
Japan	Gifu Heart Center	Gifu
Japan	Minamino Cardiovascular Hospital	Hachioji	Tokyo
Japan	Tokyo Angel Hospital	Hachioji	Tokyo
Japan	Hakodate Municipal Hospital	Hakodate	Hokkaido
Japan	Hakodate National Hospital	Hakodate	Hokkaido
Japan	Public Central Hospital of Matto Ishikawa	Hakusan	Ishikawa
Japan	National Hospital Organization Hamada Medical Center	Hamada	Shimane
Japan	National hospital Organization Mito Medical Center	Higashiibaraki	Ibaraki
Japan	Hyogo Prefectural Harima-Himeji General Medical Center	Himeji	Hyogo
Japan	Hiroshima City Hiroshima Citizens Hospital	Hiroshima
Japan	Iida Hospital	Iida	Nagano
Japan	Nippon Medical School Chiba Hokusoh Hospital	Inzai	Chiba
Japan	Nihon University Itabashi Hospital	Itabashi-ku	Tokyo
Japan	Nakamura Cardiovascular Clinic	Itoshima	Fukuoka
Japan	Kagoshima Medical Center	Kagoshima
Japan	Tenyoukai Central Clinic	Kagoshima
Japan	Kanazawa Medical University Hospital	Kahoku-gun	Ishikawa
Japan	Ishikawa Prefectural Central Hospital	Kanazawa	Ishikawa
Japan	National Hospital Organization Kanazawa Medical Center	Kanazawa	Ishikawa
Japan	Mitoyo General Hospital	Kanonji	Kagawa
Japan	Oosumikanoya Hospital	Kanoya	Kagoshima
Japan	Ibaraki Prefectural Central Hospital	Kasama	Ibaraki
Japan	Kasugai Municipal Hospital	Kasugai	Aichi
Japan	Kawaguchi Cardiovascular and Respiratory Hospital	Kawaguchi	Saitama
Japan	The Veritas Hospital	Kawanishi	Hyogo
Japan	Kimitsu Chuo Hospital	Kisarazu	Chiba
Japan	Kishiwada Tokushukai Hospital	Kishiwada	Osaka
Japan	North Alps Medical Center Azumi Hospital	Kitaazumi-gun	Nagano
Japan	Kokura Memorial Hospital	Kitakyushu	Fukuoka
Japan	Steel Memorial Yawata Hospital	Kitakyushu	Fukuoka
Japan	Kobe City Medical Center General Hospital	Kobe	Hyogo
Japan	Chikamori Hospital	Kochi
Japan	Yamanashi Prefectural Central Hospital	Kofu	Yamanashi
Japan	Komatsu Municipal Hospital	Komatsu	Ishikawa
Japan	Asama Nanroku Komoro Medical Center	Komoro	Nagano
Japan	Kumamoto Kinoh Hospital	Kumamoto
Japan	National Hospital Organization Kyoto Medical Center	Kyoto
Japan	Rakuwakai Otowa Hospital	Kyoto
Japan	Machida Municipal Hospital	Machida	Tokyo
Japan	Matsuyama Shimin Hospital	Matsuyama	Ehime
Japan	National Hospital Organization Tokyo Medical Center	Meguro-ku	Tokyo
Japan	Tokyo Saiseikai Central Hospital	Minato	Tokyo
Japan	Mito Saiseikai General Hospital	Mito	Ibaraki
Japan	Hayama Heart Center	Miura-gun	Kanagawa
Japan	Miyazaki Medical Association Hospital	Miyazaki
Japan	Iwate Prefectural Central Hospital	Morioka	Iwate
Japan	Japan Community Healthcare. Organization Chukyo Hospital	Nagoya	Aichi
Japan	Japanese RedCross Aichi Medical Center Nagoya Daini Hospital	Nagoya	Aichi
Japan	R.I.A.C Naha City Hospital	Naha	Okinawa
Japan	Go Neurosurgical Clinic	Nakagawa	Fukuoka
Japan	Hokushin General Hospital	Nakano	Nagano
Japan	Oita Prefectural Hospital	Oita
Japan	Okayama City General Medical Center Okayama City Hospital	Okayama
Japan	Okayama Rosai Hospital	Okayama
Japan	The Sakakibara Heart Institute of Okayama	Okayama
Japan	Omihachiman Community Medical Center	Omihachiman	Shiga
Japan	Fukuoka Shin Mizumaki Hospital	Onga-gun	Fukuoka
Japan	Onga Nakama Medical Association Onga Hospital	Onga-gun	Fukuoka
Japan	Japan Community Health Care Organization Osaka Hospital	Osaka
Japan	Kitada Clinic	Osaka
Japan	Nippon Life Hospital	Osaka
Japan	Osaka Police Hospital	Osaka
Japan	Osaka Saiseikai Nakatsu Hospital	Osaka
Japan	Sakurabashi Watanabe Hospital	Osaka
Japan	Saga Memorial Hospital	Saga
Japan	Iwatsuki-minami Hospital	Saitama
Japan	Sainokuni Higashiomiya Medical Center	Saitama
Japan	Sanai hospital	Saitama
Japan	Toho University Sakura Medical Center	Sakura	Chiba
Japan	Hanaoka Seishu Memorial Hospital	Sapporo	Hokkaido
Japan	Matsuda Cardiovascular clinic	Sapporo	Hokkaido
Japan	Mita Internist and Cardiology Clinic	Sapporo	Hokkaido
Japan	Miyanomori Memorial Hospital	Sapporo	Hokkaido
Japan	Miyanosawa Clinic of Internal Medicine and Cardiology	Sapporo	Hokkaido
Japan	Sapporo Higashi Tokushukai Hospital	Sapporo	Hokkaido
Japan	Teine Keijinkai Hospital	Sapporo	Hokkaido
Japan	Sendai Cardiovascular Center	Sendai	Miyagi
Japan	Tohoku Medical and Pharmaceutical University Hospital	Sendai	Miyagi
Japan	Dokkyo Medical University Hospital	Shimotsuga-gun	Tochigi
Japan	Tokyo Yamate Medical Center	Shinjuku-ku	Tokyo
Japan	Shirakawa Kosei General Hospital	Shirakawa	Fukushima
Japan	Shizuoka City Shizuoka Hospital	Shizuoka
Japan	JCHO Tokuyama Central Hospital	Shunan	Yamaguchi
Japan	NewHeart Watanabe Institute	Suginami-ku	Tokyo
Japan	Osaka Saiseikai Senri Hospital	Suita	Osaka
Japan	Japanese Red Cross Society Suwa Hospital	Suwa	Nagano
Japan	Suzuka Chuo General Hospital	Suzuka	Mie
Japan	National Hospital Organization Disaster Medical Center	Tachikawa	Tokyo
Japan	Kagawa Prefectural Central Hospital	Takamatsu	Kagawa
Japan	Higashi Takarazuka Satoh Hospital	Takarazuka	Hyogo
Japan	National Hospital Organization Takasaki General Medical Center	Takasaki	Gunma
Japan	Oji General Hospital	Tomakomai	Hokkaido
Japan	Tomakomai City Hospital	Tomakomai	Hokkaido
Japan	JA Toride Medical Center	Toride	Ibaraki
Japan	Toyota Kosei Hospital	Toyota	Aichi
Japan	Tsuchiura Kyodo General Hospital	Tsuchiura	Ibaraki
Japan	Urasoe General Hospital	Urasoe	Okinawa
Japan	Saiseikai Wakayama Hospital	Wakayama
Japan	Yanagawa Hospital	Yanagawa	Fukuoka
Japan	Yao Tokushukai General Hospital	Yao	Osaka
Japan	Yokohama City University Medical Center	Yokohama	Kanagawa
Japan	Yokohama Sakae Kyosai Hospital	Yokohama	Kanagawa
Korea, Republic of	Hallym University Sacred Heart Hospital	Anyang	Gyeonggido
Korea, Republic of	The Catholic University of Korea Seoul St. Mary's Hospital	Bucheon-si,	Gyeonggido
Korea, Republic of	Dong-A University Hospital	Busan
Korea, Republic of	Pusan National University Hospital	Busan	Busan Gwang''yeogsi
Korea, Republic of	Keimyung University Dongsan Medical Center	Daegu
Korea, Republic of	Kyungpook National University Hospital	Daegu	Daegu Gwang''yeogsi
Korea, Republic of	Chonnam National University Hospital	Gwangju
Korea, Republic of	Gachon University Gil Medical Center	Incheon
Korea, Republic of	Korea University Anam Hospital	Seongbuk
Korea, Republic of	Bundang Cha Hospital	Seongnam-si	Gyeonggido
Korea, Republic of	Seoul National University Bundang Hospital	Seongnam-si	Gyeonggido
Korea, Republic of	Asan Medical Center	Seoul
Korea, Republic of	Chung-Ang University Hospital	Seoul
Korea, Republic of	Samsung Medical Center	Seoul
Korea, Republic of	Seoul National University Hospital	Seoul
Korea, Republic of	Severance Hospital, Yonsei University Health System	Seoul
Korea, Republic of	The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital	Seoul	Seoul Teugbyeolsi
Korea, Republic of	Ajou University Hospital	Suwon	Gyeonggido
Korea, Republic of	Uijeongbu ST. Mary's Hospital	Uijeongbu	Gyeonggido
Korea, Republic of	Yonsei University Wonju Christian Hospital	Wonju	Gang''weondo
Latvia	Daugavpils Regional Hospital	Daugavpils
Latvia	Doctor's Practice in Cardiology	Daugavpils
Latvia	SIA ARI Med	Daugavpils
Latvia	Rutas Eglites GP Practice	Kuldiga
Latvia	Liepaja Regional Hospital	Liepaja
Latvia	Lija Mora physician practice	Ogre
Latvia	1st Riga Clinical Hospital	Riga
Latvia	APS Clinic	Riga
Latvia	Health Center 4	Riga
Latvia	Health Center Adoria	Riga
Latvia	P. Stradins Clinical University Hospital	Riga
Latvia	Riga East Clinical University Hospital "Gailezers"	Riga
Latvia	Vidzemes Hospital	Valmiera
Latvia	Gita Rancane - cardiology private practice	Ventspils
Lithuania	Hospital of LT University of Health Sciences Kaunas Clinics	Kaunas
Lithuania	InMedica clinic Zaliakalnis	Kaunas
Lithuania	Kardiolitos klinikos / BMP	Kaunas
Lithuania	LUHS Kauno Hospital (Josvainiu str.)	Kaunas
Lithuania	LUHS Kauno Hospital (Laisves ave.)	Kaunas
Lithuania	Mariu klinika JSC	Kaunas
Lithuania	Saules family medicine center	Kaunas
Lithuania	Kardiologijos ir reabilitacijos klinika	Klaipeda
Lithuania	Klaipeda Republican Hospital	Klaipeda
Lithuania	Klaipeda Seamen's Hospital	Klaipeda
Lithuania	Klaipeda Seamen's Hospital Cardiology Department I	Klaipeda
Lithuania	Siauliai Republican hospital	Siauliai
Lithuania	InMedica Clinic Santariskes	Vilnius
Lithuania	Vilnius University Hospital Santaros Klinikos	Vilnius
Malaysia	Hospital Sultanah Bahiyah	Alor Setar
Malaysia	University Hospital Kebangsaan Malaysia	Cheras
Malaysia	Hospital Sultanah Aminah	Johor Bahru
Malaysia	Hospital Raja Perempuan Zainab II	Kelantan
Malaysia	Hospital Universiti Sains Malaysia	Kelantan
Malaysia	Institute Jantung Negara	Kuala Lumpur
Malaysia	University Malaya Medical Centre	Kuala Lumpur
Malaysia	Hospital Tengku Ampuan Afzan	Pahang
Malaysia	Hospital Seberang Jaya	Pulau Pinang
Malaysia	Sarawak General Hospital	Sarawak
Malaysia	Sarawak Heart Centre	Sarawak
Malaysia	Hospital Al-Sultan Abdullah (UiTM Hospital)	Selangor
Malaysia	Hospital Pengajar Universiti Putra Malaysia	Selangor
Malaysia	Hospital Serdang	Selangor
Malaysia	Seremban Hospital Neurology	Seremban
Netherlands	Ziekenhuis Amstelland	Amstelveen
Netherlands	Academisch Medisch Centrum (AMC)	Amsterdam
Netherlands	Gelre Ziekenhuizen Apeldoorn / Cardiology	Apeldoorn
Netherlands	Rijnstate | Arnhem - Internal Medicine Department - Vascular Research	Arnhem
Netherlands	Rode Kruis Ziekenhuis	Beverwijk
Netherlands	Tergooiziekenhuizen-Blaricum	Blaricum
Netherlands	Amphia Breda | Department of Cardiology, BMC Research	Breda
Netherlands	HagaZiekenhuis | Cardiology Department	Den Haag
Netherlands	Van Weel-Bethesda Ziekenhuis	Dirksland
Netherlands	Albert Schweitzer Ziekenhuis, Dordwijk	Dordrecht
Netherlands	Catharina Hospital | Cardiology Department	Eindhoven
Netherlands	Treant locatie Bethesda	Emmen
Netherlands	MST|TCT-Foundation Cardiovascular Research and Education	Enschede
Netherlands	Admiraal de Ruyterziekenhuis	Goes	Zeeland
Netherlands	Beatrixziekenhuis	Gorinchem
Netherlands	Martini Ziekenhuis, Locatie van Swieten	Groningen
Netherlands	Universitair Medisch Centrum Groningen	Groningen
Netherlands	Spaarne Gasthuis - locatie Zuid	Haarlem
Netherlands	Saxenburgh Medisch Centrum	Hardenberg
Netherlands	Bravis Ziekenhuis	Roosendaal
Netherlands	Ziekenhuis Rivierenland | Cardiology Research Department	Tiel
Netherlands	VieCuri - Medisch Centrum voor Noord-Limburg locatie Venlo	Venlo
Netherlands	Zaans Medisch Centrum	Zaandam
Norway	Ålesund Sykehus, Kardiologisk Seksjon	Ålesund
Norway	Nordlandssykehuset HF	Bodø
Norway	Vestre Viken HF - Drammen Sykehus Cardiology	Drammen
Norway	Sykehuset Innlandet HF Elverum	Elverum
Norway	Sykehuset Østfold HF Fredrikstad	Fredrikstad
Norway	Vestre Viken HF - Bærum Sykehus Cardiology	Gjettum
Norway	Sykehuset Innlandet HF Gjøvik	Gjøvik
Norway	Universitetssykehuset i Nord Norge, Harstad	Harstad
Norway	Sykehuset Innlandet HF Lillehammer	Lillehammer
Norway	Helse Møre og Romsdal HF	Molde
Norway	Akershus University Hospital Cardiology Department	Nordbyhagen
Norway	Diakonhjemmets sykehus	Oslo
Norway	Oslo Universitetssykehus HF, Rikshospitalet	Oslo
Norway	OUS Ullevål Cardiology Department	Oslo
Norway	Skedsmo Medisinske Senter	Skedsmokorset
Norway	Stavanger Universitetssjukehus	Stavanger
Norway	Universitetssykehuset Nord-Norge HF Tromsø	Tromsø
Poland	KLIMED Marek Klimkiewicz	Bialystok
Poland	Uniwersytecki Szpital Kliniczny w Bialymstoku	Bialystok
Poland	Centrum Medyczne KerMed	Bydgoszcz
Poland	MICS Centrum Medyczne Bydgoszcz	Bydgoszcz
Poland	Uniwersyteckie Centrum Kliniczne	Gdansk
Poland	Samodzielny Publiczny Specjalistyczny Szpital Zachodni	Grodzisk Mazowiecki
Poland	CLINICAL MEDICAL RESEARCH Sp. z o. o.	Katowice
Poland	Vita Longa Sp. z o.o.	Katowice
Poland	Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn	Krakow
Poland	Centrum Terapii Wspolczesnej	Lodz
Poland	MED-GASTR Sp. z o.o. Sp. k.	Lodz
Poland	Centrum Medyczne Ogrodowa G. i M. Kania Lekarze i Lekarze Dentysci Spólka Partnerska z siedziba w Skierniewicach	Lowicz
Poland	1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie	Lublin
Poland	NZOZ "Twoja Przychodnia" Sp. z o.o.	Lublin
Poland	Etyka Osrodek Badan Klinicznych	Olsztyn
Poland	Futuremeds sp. z o. o.	Olsztyn
Poland	NZOZ Heureka	Piaseczno
Poland	Irmed Klimkiewicz, Rudziewicz-Kowalska Sp.j.	Piotrkow Trybunalski
Poland	Solumed Centrum Medyczne	Poznan
Poland	KO-MED Centra Kliniczne Pulawy	Pulawy
Poland	EMED Centrum Uslug Medycznych Ewa Smialek	Rzeszow
Poland	ClinMedica Research Sp. z o.o.	Skierniewice
Poland	"Nowe Zdrowie-Ck" Kieltucki I Wspolnicy Spolka Jawna	Staszow
Poland	Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji	Warszawa
Poland	NBR Polska Tomasz Klodawski	Warszawa
Poland	KO-MED Centra Kliniczne Zamosc	Zamosc
Portugal	Hospital Garcia de Orta | Research Department	Almada
Portugal	Centro Clinico Academico Braga | Braga, Portugal	Braga
Portugal	Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research Unit	Coimbra
Portugal	Centro Hospitalar Universitario Cova de Beira | Clinical Research Department	Covilha	Castelo Branco
Portugal	Centro Hospitalar de Tamega e Sousa | Hospital Padre Americo - Cardiology Department	Guilhufe
Portugal	Hospital da Senhora da Oliveira | Clinical Research Department	Guimaraes, Braga	Braga
Portugal	Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center	Leiria
Portugal	Centro Hospitalar de Lisboa Ocidental | Clin Res Dept	Lisboa
Portugal	Centro Hospitalar Universitário de Lisboa Norte | Heart and Vessels Department	Lisboa
Portugal	Lusiadas | Hospital Lusiadas Lisboa - Lusiadas Knowledge Center	Lisboa
Portugal	Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica	Lisboa
Portugal	ULSM - Hospital Pedro Hispano	Matosinhos	Porto
Portugal	CHUSJ - Hospital Sao Joao	Porto
Portugal	Ucardio | Cardiology Department	Riachos	Santarém
Portugal	Hospital da Luz - Setubal	Setubal	Setúbal
Portugal	Centro Hospitalar Vila Nova de Gaia/Espinho | Unit 1 - Clinical Research Office	Vila Nova de Gaia
Portugal	Centro Hospitalar De Tras os Montes e Alto Douro, EPE | Hospital Sao Pedro - Centro de investigacao clinica	Vila Real
Romania	Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare	Baia Mare
Romania	Emergency County Hospital, Braila	Braila
Romania	S.C Thera Card S.R.L	Brasov
Romania	S.C. Centrul Medical de Diagn si Tratam Ambulator Neomed SRL	Brasov
Romania	Emergency Institute for Cardiovascular Diseases	Bucharest
Romania	Spitalul Clinic de Urgenta Sf. Ioan	Bucharest
Romania	Emergency Institute for Cardiovascular Diseases	Bucuresti
Romania	Spitalul Clinic Colentina	Bucuresti
Romania	Spitatul Universitar de Urgenta Bucuresti	Bucuresti
Romania	Niculae Stancioiu Heart Institute Cluj-Napoca	Cluj Napoca
Romania	Spitalul Clinic de Recuperare Cluj-Napoca	Cluj Napoca
Romania	CardioMed	Cluj-Napoca
Romania	S.C. Sal Med SRL	Pitesti
Romania	Spitalul Judetean de Urgenta Satu Mare	Satu Mare
Romania	Spitalul de urgenta Sf. Ioan Cel Nou	Suceava
Romania	CMI. Dr. Podoleanu Cristian	Targu Mures	Mures
Romania	Emergency Institute of Cardiovascular Diseases & Transplant	Targu Mures
Romania	S.C. Cardio Med S.R.L.	Targu Mures
Romania	Municipal Clinical Emergency Hospital of Timisoara	Timisoara	Timis
Romania	Timisoara Institute of Cardiovascular Diseases	Timisoara
Singapore	Changi General Hospital	Singapore
Singapore	National Heart Centre Singapore	Singapore
Singapore	National University Hospital	Singapore
Singapore	Ng Teng Fong General Hospital	Singapore
Singapore	Sengkang General Hospital	Singapore
Singapore	SingHealth Polyclinics - Pasir Ris	Singapore
Singapore	Tan Tock Seng Hospital	Singapore
Slovakia	ALIAN s.r.o.	Bardejov
Slovakia	GALENUM s.r.o.	Bratislava
Slovakia	Kardiosanus | Bratislava, Slovakia	Bratislava
Slovakia	Nemocnica s poliklinikou Brezno, n.o.	Brezno
Slovakia	KARDIO R s.r.o.	Kosice
Slovakia	Medical Group Kosice s.r.o. | Kosice, Slovakia	Kosice
Slovakia	KARDIO-ANGIO s.r.o.	Levice
Slovakia	KardioLEV s.r.o.	Levoca
Slovakia	Internal and Diabetes Clinic - IN-DIA s.r.o. | Lucenec, Slovakia	Lucenec
Slovakia	KARDIO 1 | Lucenec, Slovakia	Lucenec
Slovakia	KardioMed s.r.o.	Lucenec
Slovakia	ORALEK, s.r.o.	Namestovo
Slovakia	Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department	Nitra
Slovakia	Specializovana nemocnica sv. Svorada Zobor, n.o.	Nitra
Slovakia	KaCH, s.r.o.	Nove Zamky
Slovakia	BENIMED s.r.o.	Piestany
Slovakia	Medikard | Department of Internal Medicine	Presov
Slovakia	MEDISPOL s.r.o.	Presov
Slovakia	Interna SK s.r.o.	Svidnik
Slovakia	Kardiologicka ambulancia Trnava, MUDr. Vladimir Macek	Trnava
Slovakia	Medivasa s.r.o.	Zilina
Spain	University Hospital of A Coruna | Cardiology department	A Coruña
Spain	Hospital General Universitario de Alicante Doctor Balmis | Cardiology Department	Alicante
Spain	Hospital de la Santa Creu i Sant Pau | Cardiology Department	Barcelona
Spain	Hospital Quironsalud Barcelona | Internal Medicine Department	Barcelona
Spain	Vall d'Hebron Barcelona Hospital Campus | Vall d'Hebron Hospital Universitario - Cardiology Department	Barcelona
Spain	Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial	Ferrol	A Coruña
Spain	Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke Prevention	L'Hospitalet de Llobregat	Barcelona
Spain	Hospital Alta Resolucion de Lebrija | Cardiology Service Department	Lebrija	Sevilla
Spain	H. Universitario 12 de Octubre - Cardiologia	Madrid
Spain	Hospital Universitario de La Princesa | Internal Medicine Department	Madrid
Spain	Hospital Universitario La Paz | Cardiology Department - AF, Stroke Prevention	Madrid
Spain	Hospital Universitario La Paz | IdiPAZ - Neurology Department	Madrid
Spain	Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna	Madrid
Spain	Hospital Universitario Virgen de la Victoria | Cardiology Department	Malaga	Málaga
Spain	Hospital Clinico Universitario Virgen de la Arrixaca | Cardiology Department	Murcia
Spain	Hospital Universitario Central de Asturias | Servicio de Cardiologia	Oviedo	Asturias
Spain	Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine Department	Sanlucar de Barrameda	Cádiz
Spain	Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department	Santiago de Compostela	A Coruña
Spain	Hospital Universitario Virgen del Rocio | Hospital General - Departmaneto de Cardiologia y Cirugia Cardiovascular	Sevilla
Spain	Hospital Alta Resolucion de Utrera | Cardiology Service Department	Utrera	Sevilla
Spain	Hospital General Universitario de Valencia | Cardiology Department	Valencia
Spain	La Fe University and Polytechnic Hospital | Cardiology Department	Valencia
Spain	Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine Department	Villamartin	Cádiz
Sweden	Södra Älvsborgs Sjukhus	Borås
Sweden	Falu Lasarett	Falun
Sweden	SU/Östra	Göteborg
Sweden	Helsingborgs Lasarett	Helsingborg
Sweden	Universitetssjukhuset i Linköping	Linköping
Sweden	Clemenstorget Hjärtmottagning	Lund
Sweden	Skånes Universitetssjukhus	Lund
Sweden	SU/Mölndal	Mölndal
Sweden	Vrinnevisjukhuset	Norrköping
Sweden	Universitetssjukhuset Örebro	Örebro
Sweden	Skellefteå Lasarett	Skellefteå
Sweden	Danderyds sjukhus	Stockholm
Sweden	Karolinska Universitetssjukhuset	Stockholm
Sweden	Karolinska Universitetssjukhuset Huddinge Stockholm	Stockholm
Sweden	Södersjukhuset AB	Stockholm
Sweden	Norrlands Universitetssjukhus, Umea	Umea
Sweden	Akademiska Sjukhuset	Uppsala
Sweden	Västmanlands Sjukhus Västerås	Västerås
Switzerland	Kantonsspital Aarau	Aarau	Aargau
Switzerland	Kantonsspital Baden	Baden
Switzerland	Inselspital Universitätsspital Bern	Bern
Switzerland	Cardiocentro Ticino	Lugano
Switzerland	Kantonsspital St. Gallen	Saint Gallen	Sankt Gallen
Switzerland	UniversitätsSpital Zürich	Zürich
Taiwan	Changhua Christian Hospital	Changhua
Taiwan	Mackay Memorial Hospital - Hsinchu Branch	Hsinchu
Taiwan	Buddhist Tzu-Chi General Hospital, Hualien	Hualien
Taiwan	Chang Gung Memorial Hospital Kaohsiung	Kaohsiung
Taiwan	E-Da Hospital	Kaohsiung
Taiwan	Veterans General Hospital	Kaohsiung
Taiwan	Kaohsiung Medical University Chung-Ho Memorial Hospital	Kaohsiung City	Kaohsiung
Taiwan	MacKay Memorial Hospital Tamsui Branch	New Taipei City	Taipei
Taiwan	China Medical University Hospital	Taichung
Taiwan	Chung Shan Medical University Hospital	Taichung
Taiwan	Taichung Veterans General Hospital	Taichung
Taiwan	Chi Mei Medical Center	Taikang	Tainan
Taiwan	National Cheng Kung University Hospital	Tainan
Taiwan	Cathay General Hospital	Taipei
Taiwan	Mackay Memorial Hospital	Taipei
Taiwan	National Taiwan University Hospital	Taipei
Taiwan	Taipei Medical University Hospital	Taipei
Taiwan	Taipei Municipal Wanfang Hospital	Taipei
Taiwan	Taipei Veterans General Hospital	Taipei
Taiwan	Shin Kong Wu Ho-Su Memorial Hospital	Taipei City	Taipei
Taiwan	Tri-Service General Hospital	Taipei City
Taiwan	Chang Gung Memorial Hospital at Linkou	Taoyuan
Taiwan	National Yang Ming Chiao Tung University Hospital	Yilan City	Ilan
Turkey	S.B.U. Adana Sehir Egitim ve Arastirma Hastanesi	Adana
Turkey	Afyonkarahisar Saglik Bilimleri Universitesi	Afyonkarahisar
Turkey	Baskent Universitesi Tip Fakultesi Hastanesi	Ankara
Turkey	Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital	Ankara
Turkey	Akdeniz Universitesi Tip Fakultesi Hastanesi	Antalya
Turkey	Hitit Universitesi Tip Fakultesi	Corum
Turkey	Ataturk Universitesi Tip Fakultesi	Erzurum
Turkey	Eskisehir Osmangazi Universitesi Tip Fakultesi	Eskisehir
Turkey	Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.	Istanbul
Turkey	Istanbul Universitesi Cerrahpasa - Kardiyoloji Anabilim Dali	Istanbul
Turkey	Marmara Uni. Tip Fak. Pendik EAH Kardiyoloji	Istanbul
Turkey	Dokuz Eylul Universitesi Tip Fakultesi	Izmir
Turkey	Izmir Ekonomi Universitesi Medikal Point Hastanesi	Izmir
Turkey	Erciyes Universitesi Tip Fakultesi	Kayseri
Turkey	Kocaeli Universitesi Tip Fakultesi	Kocaeli
Turkey	Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti	Kutahya
Turkey	Saglik Bilimleri Univ. Samsun EAH Kardiyoloji Departmani	Samsun
United Kingdom	Wansbeck General Hospital	Ashington	Northumberland
United Kingdom	North Hampshire Hospital	Basingstoke	Hampshire
United Kingdom	Soho Health Centre, Future Meds	Birmingham	West Midlands
United Kingdom	Ely Bridge Medical Centre	Cardiff
United Kingdom	Countess of Chester Hospital	Chester	Cheshire
United Kingdom	Chesterfield Royal Hospital	Chesterfield	Derbyshire
United Kingdom	St Richard's Hospital	Chichester	West Sussex
United Kingdom	Craigavon Area Hospital	Craigavon	North Ireland
United Kingdom	Russells Hall Hospital	Dudley	West Midlands
United Kingdom	Staploe Medical Centre	Ely	Cambridgeshire
United Kingdom	Glasgow Royal Infirmary | Stroke Unit	Glasgow	Glasgow City
United Kingdom	Northwick Park Hospital	Harrow	London
United Kingdom	University Hospitals Leicester	Leicester	Leicestershire
United Kingdom	Heart and Chest Hospital	Liverpool
United Kingdom	Charing Cross Hospital	London
United Kingdom	King's College Hospital - NHS Foundation Trust	London
United Kingdom	Queen Elizabeth the Queen Mother Hospital	Margate	Kent
United Kingdom	James Cook University Hospital South Tees	Middlesborough	North Yorkshire
United Kingdom	Freeman Hospital	Newcastle	Tyne And Wear
United Kingdom	Poole Hospital NHS Trust	Poole	Dorset
United Kingdom	Lister Hospital	Stevenage	Hertfordshire
United Kingdom	Torbay Hospital	Torbay	Devon
United Kingdom	Future Meds - Bromborough	Wirral
United Kingdom	Worcestershire Acute Hospital Trust	Worcester	Worcestershire
United States	Cambridge Medical Trials	Alexandria	Louisiana
United States	PharmaTex Research, LLC	Amarillo	Texas
United States	Accellacare-Ames	Ames	Iowa
United States	AnMed Clinical Research	Anderson	South Carolina
United States	Grady Memorial Hospital	Atlanta	Georgia
United States	Johns Hopkins Hospital/Health System	Baltimore	Maryland
United States	LifeBridge Health | Sinai Hospital | Platelet and Thrombosis Research Department	Baltimore	Maryland
United States	St. Agnes Hospital	Baltimore	Maryland
United States	Northeast Cardiology Associates	Bangor	Maine
United States	Ochsner Clinic Foundation	Baton Rouge	Louisiana
United States	McLaren Bay Region Medical Center	Bay City	Michigan
United States	Florida Premier Cardiology	Boynton Beach	Florida
United States	Integrity Clinical Research | Cardiology Associates of South Florida	Boynton Beach	Florida
United States	Cardiovascular and Vein Center of Florida	Bradenton	Florida
United States	Nova Clinical Research | Brandenton, FL	Bradenton	Florida
United States	Advanced Heart Care, LLC | Bridgewater, NJ	Bridgewater	New Jersey
United States	Holston Medical Group - Bristol	Bristol	Tennessee
United States	Cooper Specialty Care at Voorhees	Camden	New Jersey
United States	Capital Area Research, LLC	Camp Hill	Pennsylvania
United States	Aultman | Aultman Hospital Main Campus - Clinical Trials	Canton	Ohio
United States	University of North Carolina	Chapel Hill	North Carolina
United States	Erlanger Health, Inc.	Chattanooga	Tennessee
United States	Clearwater Cardiovascular Associates | Clearwater, FL	Clearwater	Florida
United States	Johns Hopkins University	Columbia	Maryland
United States	Life Spring Research	Coral Gables	Florida
United States	Valley Clinical Trials, Inc. | Covina, CA	Covina	California
United States	Cardiovascular Associates Research, LLC	Covington	Louisiana
United States	Science 37	Culver City	California
United States	NSC Research INC	Cumming	Georgia
United States	Southwest Family Medicine Associates	Dallas	Texas
United States	Cardiology Associates Research Company	Daytona Beach	Florida
United States	Cardiology Consultants, PA	Daytona Beach	Florida
United States	Heller Heart Health	Delray Beach	Florida
United States	Prime Revival Reserach Institute, LLC | Denton, TX	Denton	Texas
United States	Henry Ford Health System	Detroit	Michigan
United States	SEC Clinical Research	Dothan	Alabama
United States	Doylestown Hospital	Doylestown	Pennsylvania
United States	Alta Pharmaceutical Research Center, LLC	Dunwoody	Georgia
United States	Duke Univ. Medical Center	Durham	North Carolina
United States	Duke University School of Medicine	Durham	North Carolina
United States	David Turbay MD PLLC	El Paso	Texas
United States	Midwest Cardiovascular Research and Education Foundation	Elkhart	Indiana
United States	Inova Fairfax Hospital - Fairfax	Fairfax	Virginia
United States	Eastern Shore Research Institute, LLC | Fairhope, AL	Fairhope	Alabama
United States	Virginia Heart	Falls Church	Virginia
United States	Lillestol Research, LLC	Fargo	North Dakota
United States	Aa Mrc, Llc	Flint	Michigan
United States	Piedmont Research Partners LLC	Fort Mill	South Carolina
United States	Anderson Medical Research LLC	Fort Washington	Maryland
United States	Texas Health Physicians Group - Fort Worth	Fort Worth	Texas
United States	Texas Health Research & Education Institute	Fort Worth	Texas
United States	Malcom Randall VA Medical Ctr	Gainesville	Florida
United States	Stern Cardiovascular Center	Germantown	Tennessee
United States	Northshore Medical Center	Glenview	Illinois
United States	Nebraska Heart Institute- Grand Island	Grand Island	Nebraska
United States	Medication Management, LLC	Greensboro	North Carolina
United States	Cardiology Associates of Northwest Indiana, PC	Hammond	Indiana
United States	Pennsylvania State University College of Medicine	Hershey	Pennsylvania
United States	Indago Research & Health Center, Inc.	Hialeah	Florida
United States	Houston Methodist Hospital	Houston	Texas
United States	IU Health Physicians Cardiology	Indianapolis	Indiana
United States	Nature Coast Clinical Research, LLC	Inverness	Florida
United States	Apex Cardiology, LLC	Jackson	Tennessee
United States	Jackson Heart Clinic | Jackson, MS	Jackson	Mississippi
United States	University of Florida - Jacksonville	Jacksonville	Florida
United States	Kettering Health Network | Research Institute	Kettering	Ohio
United States	TCR Institute	Kingwood	Texas
United States	Accellacare | Mt. Pleasant, South Carolina	Ladson	South Carolina
United States	Sparrow Clinical Research Institute | Sparrow Hospital - Clinical Research Department	Lansing	Michigan
United States	Baptist Health Lexington	Lexington	Kentucky
United States	NJ Medcare/NJ Heart	Linden	New Jersey
United States	Arkansas Cardiology - Little Rock	Little Rock	Arkansas
United States	South Denver Cardiology Associates, PC	Littleton	Colorado
United States	VA Long Beach Healthcare System	Long Beach	California
United States	Heart Vein & Vascular | Longwood, FL	Longwood	Florida
United States	VA Greater Los Angeles Healthcare System	Los Angeles	California
United States	Baptist Health Medical Group - Louisville Cardiology	Louisville	Kentucky
United States	Garden State Heart Care	Manalapan	New Jersey
United States	Carient Heart and Vascular	Manassas	Virginia
United States	M Health Fairview	Maplewood	Minnesota
United States	Rama Research LLC | Marion, OH	Marion	Ohio
United States	North Dallas Research Associate | McKinney, TX	McKinney	Texas
United States	North Texas Research Associates	McKinney	Texas
United States	St. Luke's Health System | St. Luke's Clinic - Idaho Cardiology Associates	Meridian	Idaho
United States	Circuit Clinical/Crystal Run	Middletown	New York
United States	Minneapolis VA Medical Center	Minneapolis	Minnesota
United States	Mobile Heart Specialists, PC	Mobile	Alabama
United States	Clinical Trials of America, Inc.	Mount Airy	North Carolina
United States	Inspira Medical Centers | Clinical Research Office	Mullica Hill	New Jersey
United States	Advanced Research for Health Improvement	Naples	Florida
United States	Southwest Florida Research | Naples, FL	Naples	Florida
United States	Vanderbilt University Medical Center	Nashville	Tennessee
United States	Ochsner Medical Center - New Orleans	New Orleans	Louisiana
United States	NYU Langone Health | NYU Langone Medical Associates Chelsea - Cardiovascular Research	New York	New York
United States	Radin Cardiovascular Medical Group, Inc.	Newport Beach	California
United States	York Clinical Research	Norfolk	Virginia
United States	Amicis Research Center | Northridge, CA	Northridge	California
United States	Cardiology Associates of Fairfield County, P.C. | Stamford, CT	Norwalk	Connecticut
United States	Affinity Health Research Institute | Oak Brook, IL	Oak Brook	Illinois
United States	South Oklahoma Heart Research, LLC	Oklahoma City	Oklahoma
United States	Research Integrity, LLC	Owensboro	Kentucky
United States	Cardiology Partners Clinical Research Institute	Palm Beach Gardens	Florida
United States	Baptist Heart and Vascular/Cardiology Consultants	Pensacola	Florida
United States	Thomas Jefferson University Hospitals	Philadelphia	Pennsylvania
United States	Styde Research LLC | Plano, TX	Plano	Texas
United States	Peace River Cardiovascular Center | Port Charlotte, FL	Port Charlotte	Florida
United States	Sound Medical Research	Port Orchard	Washington
* Note: There are 1037 locations in all - only the first 1000 are shown.

Sponsors (1)

Lead Sponsor	Collaborator
Bayer

Countries where clinical trial is conducted

United States,  Argentina,  Australia,  Austria,  Belgium,  Brazil,  Bulgaria,  Canada,  China,  Czechia,  Denmark,  Estonia,  Finland,  France,  Germany,  Greece,  Hungary,  India,  Israel,  Italy,  Japan,  Korea, Republic of,  Latvia,  Lithuania,  Malaysia,  Netherlands,  Norway,  Poland,  Portugal,  Romania,  Singapore,  Slovakia,  Spain,  Sweden,  Switzerland,  Taiwan,  Turkey,  United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time to first occurrence of composite of stroke or systemic embolism		Up to 34 months
Primary	Time to first occurrence of ISTH major bleeding	ISTH = International Society on Thrombosis and Hemostasis	Up to 34 months
Primary	Time to first occurrence of composite of stroke, systemic embolism, or ISTH major bleeding		Up to 34 months
Secondary	Time to first occurrence of composite of ischemic stroke or systemic embolism		Up to 34 months
Secondary	Time to first occurrence of all-cause mortality		Up to 34 months
Secondary	Time to first occurrence of ischemic stroke		Up to 34 months
Secondary	Time to first occurrence of CV death	CV = cardiovascular	Up to 34 months
Secondary	Time to first occurrence of composite of CV death, stroke, or myocardial infarction		Up to 34 months
Secondary	Time to first occurrence of composite of ISTH major or clinically relevant non-major bleeding		Up to 34 months
Secondary	Time to first occurrence of clinically relevant non-major bleeding		Up to 34 months
Secondary	Time to first occurrence of hemorrhagic stroke		Up to 34 months
Secondary	Time to first occurrence of intracranial hemorrhage		Up to 34 months
Secondary	Time to first occurrence of fatal bleeding		Up to 34 months
Secondary	Time to first occurrence of minor bleeding		Up to 34 months
Secondary	Time to first occurrence of composite of stroke, systemic embolism, ISTH major bleeding, or all-cause mortality		Up to 34 months
Secondary	Time to first occurrence of composite of disabling stroke (mRS = 3), critical bleeding, or all-cause mortality	mRS = modified Rankin Scale	Up to 34 months

External Links

•   Click here to find further information and, after study completion, the study results according to Bayer's transparency standards