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Inflammation in Vascular Disease — REBEL  

Atherosclerosis Clinical Trial

Official title:
The Role of Inflammation in Vascular Disease (Inflammationens Roll i kärlsjukdom)

Clinical Trial Summary

Increasing evidence suggests that systemic low-grade inflammation may be a driving force of cardiometabolic complications, such as vascular dysfunction, atherosclerosis and ischemic heart disease. Thus, we will investigate the role of inflammation in cardiovascular disease.

Clinical Trial Description

Vascular reconstruction surgeries usually require a small piece of the vessel wall to be excised. The excised vessel is generally discarded as medical waste: however, for patients participating in the study, the excised tissue will be placed in saline and collected for research use.

Tissue collected from individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and/or other manifestations of atherosclerosis, vascular tissue will be cultured ex vivo in the presence or absence of therapeutic agents, to determine if these attenuate the inflammation associated with the atherosclerotic phenotype. Furthermore, the protocol will also be carried out using vascular tissue from control patients, which have undergone vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03732612
Study type Observational
Source Göteborg University
Contact Emma Borgeson, PhD
Phone +46313420000
Email emma.borgeson@wlab.gu.se
Status Recruiting
Phase
Start date September 2, 2019
Completion date February 1, 2024
View Details
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