Atherosclerosis Clinical Trial
Official title:
Epigenetic Reprogramming of Monocytes in Patients With Coronary Atherosclerosis
In this study, the investigators will determine whether patients with documented atherosclerosis are characterized by specific epigenetic changes in circulating cells of the innate immune system, compared to patients without atherosclerosis.
Rationale: The innate immune system plays a pivotal role in the development and progression
of atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting
immunological memory after stimulation with various microorganisms, which has been termed
'trained innate immunity'. This memory is induced by epigenetic reprogramming. We
hypothesize that trained monocytes augment atherogenesis.
Objective: The main objective is to study whether patients with coronary atherosclerosis
show specific epigenetic changes in the promoter regions of pro-inflammatory cytokines and
chemokines and whether this correlates with the inflammatory phenotype of these cells.
Study design: Observational study
Study population: Adult patients who have had computed tomography coronary angiography
because of chest pain: 20 patients without atherosclerosis and 20 patients with severe
atherosclerosis will be included.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
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