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NCT03423693 Clinical Trial

Small Airway Obstruction in Asthma, COPD, ACOS

Asthma Clinical Trial

Official title:
Comparative Study on Sputum Anti-inflammatory Mediators in Patients With Asthma or Asthma and COPD Overlap (ACOS) Syndrome, and COPD

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03423693
Other study ID # Si527/2015
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 10, 2018
Est. completion date December 2019

Study information
Verified date August 2019
Source Mahidol University
Contact Kittipong Maneechotesuwan, MD, PhD
Phone 6624197757
Email kittipong.man@mahidol.ac.th
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and COPD

Description:

The data including spirometry, lung volume, impulse oscillometry, sputum data, demographic characters within 6 months are collected for later analysis. Sputum supernatants and cytospins are used to determine inflammatory and anti-inflammatory responses in those patients.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date December 2019
Est. primary completion date November 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Physician-diagnosed asthma, ACO, and COPD

- Their spirometric, IOS, lung volume, demographic data and sputum samples are available

Exclusion Criteria:

- Concomitant diseases requiring immunosuppressive therapy

- Being on treatments with NSAIDs, macrolides, statins

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• No any intervention
No any intervention is applied to any groups in this study

Locations
Country Name City State
Thailand Siriraj Hospital Bangkok Noi Bangkok

Sponsors (1)
Lead Sponsor Collaborator
Mahidol University

Country where clinical trial is conducted

Thailand, 

Outcome
Type Measure Description Time frame Safety issue
Primary Lipoxin A4, , Lipoxin A4 is measured in sputum supernatants by ELISA 1 day (single time point)
Secondary IL-33 IL-33 is measured in sputum supernatants by ELISA 1 day (single time point)
Secondary Thymic stromal lymphopoietin (TSLP) TSLP is measured in sputum supernatants by ELISA 1 day (single time point)
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