Arterial Hypertension Clinical Trial
Official title:
Evaluation of Systemic Microvascular Density and Endothelial Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation
Verified date | January 2020 |
Source | National Institute of Cardiology, Laranjeiras, Brazil |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
It has been proposed that the modulation of the activity of the sympathetic nervous system,
through renal sympathetic denervation, besides reducing blood pressure, would promote an
improvement in vascular reactivity and consequent improvement of macro and microcirculation.
The present study aimed to investigate the influence of the renal sympathetic denervation on
the skin microvascular function of patients presenting with resistant arterial hypertension.
Status | Completed |
Enrollment | 20 |
Est. completion date | January 6, 2020 |
Est. primary completion date | January 6, 2020 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Resistant arterial hypertension under pharmacological treatment Exclusion Criteria: - secondary arterial hypertension - renal dysfunction - severe kidney disease - congestive heart failure |
Country | Name | City | State |
---|---|---|---|
Brazil | National Institute of Cardiology | Rio de Janeiro |
Lead Sponsor | Collaborator |
---|---|
National Institute of Cardiology, Laranjeiras, Brazil |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cutaneous microvascular reactivity | Evaluation of microvascular reactivity using laser speckle contrast imaging | Before and one, three, six and twelve months after intervention | |
Primary | Cutaneous microvascular flow | Evaluation of the microvascular flow using laser speckle contrast imaging | Before and one, three, six and twelve months after intervention | |
Secondary | Cutaneous capillary density | Evaluation of cutaneous capillary density and reactivity using video-capillaroscopy | Before and one, three, six and twelve months after intervention |
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