Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital

Status Recruiting

Clinical Trial Summary

Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease

Clinical Trial Description

The purpose of this study is to investigate the phenomenon of cardiovascular system response to maternal hyperoxygenation in the fetus with congenital heart disease(CHD), which can provide further insight into fetal adaptations to CHD and improve our understanding of the pathophysiology of these conditions.Cases are gravidas with fetal congenital heart disease diagnosed by echocardiography various gestational weeks.The baseline fetal echocardiography parameters has obtained from these gravidas.Then the participants received 10-15 minutes hyperoxygenation, and the accordingly fetal echocardiography parameters were obtained.The objective of the study includes:(1)To investigate the response of the MCA PI to maternal hyperoxygenation in various forms of CHD. Middle cerebral artery(MCA) pulsatility index (PI) at MH will be compared to baseline at various gestational ages in a variety of types of CHD;(2)To investigate the response of the umbilical artery (UA) PI to maternal hyperoxygenation in various forms of CHD. UA PI at MH will be compared to baseline at various gestational ages in a variety of CHD; (3)To study the response of myocardial diastolic function to MH in various forms of CHD. Diastolic inflow patterns across the tricuspid and mitral valves will be measured and ductus venosus flow pattern will be evaluated at MH and compared to baseline at various gestational ages in a variety of CHD;(4)To investigate for any changes in cardiac output and the ratio of flow between the right and left ventricles in response to MH in various forms of CHD;(5)To investigate for changes in flow pattern at the aortic isthmus in those with suspicion or clear evidence of coarctation of the aorta. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03147014
Study type	Interventional
Source	Beijing Anzhen Hospital
Contact	Yanping Ruan, MD
Phone	+86 15311258732
Email	yanping.ruan@163.com
Status	Recruiting
Phase	N/A
Start date	January 1, 2016
Completion date	December 31, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01215240` - Prophylactic Peritoneal Dialysis Decreases Time to Achieve a Negative Fluid Balance After the Norwood Procedure	N/A
Completed	`NCT00513240` - Erythropoetin Neuroprotection for Neonatal Cardiac Surgery	Phase 1/Phase 2
Withdrawn	`NCT00156455` - Sleep Disordered Breathing in Children With Single Ventricle Physiology	N/A
Terminated	`NCT01445041` - Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome	Phase 1
Recruiting	`NCT04581668` - Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease	N/A
Completed	`NCT01736956` - Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome	N/A
Completed	`NCT01708863` - A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation
Recruiting	`NCT03406884` - The CHILD Trial: Hypoplastic Left Heart Syndrome Study.	Phase 1
Active, not recruiting	`NCT03079401` - Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle	Phase 1/Phase 2
Completed	`NCT02306057` - Fluid Balance in Children Undergoing Fontan Surgery	N/A
Terminated	`NCT01107990` - Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques
Completed	`NCT01883076` - Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome	Phase 1
Completed	`NCT04056416` - Physical Activity Promotion in Children and Adolescents With Single Ventricle Physiology (MedBike)	N/A
Completed	`NCT01656941` - Genetic Determinants of Congenital Heart Disease Outcomes
Completed	`NCT00464100` - Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes
Active, not recruiting	`NCT03779711` - Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome	Phase 2
Recruiting	`NCT04925024` - Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial.	Phase 2
Recruiting	`NCT02781922` - Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial)	Phase 3
Completed	`NCT01582529` - SVRII Family Factors Study
Completed	`NCT00974025` - Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients	N/A