Anxiety Disorders Clinical Trial
Official title:
Improving the Control of Fear: Healthy Adults to Pathological Anxiety
The purpose of this study is to use functional magnetic resonance imaging to investigate how
the human brain learns to form associations between neutral and emotional stimuli. The study
is based on the basic principles of Pavlovian conditioning.
When someone learns that a neutral stimulus (such as the sound of a bell) predicts an
unpleasant stimulus (such as a mild electrical shock), the neutral stimulus takes on the
properties of an emotional stimulus.
The investigators are interested in the neural processes involved in this learning in people
with a clinical anxiety disorder and posttraumatic stress disorder (PTSD).
This study uses functional MRI in people with anxiety and stress-related disorders to
evaluate the neural correlates of fear conditioning and extinction. During fear conditioning
participants see a picture of a face that predicts a mild electrical shock to the wrist.
Participants then return the next day to the scanner for a test of fear expression 24-hours
after fear conditioning. The investigators are simultaneously measuring autonomic arousal in
the scanner using measures of skin conductance responses (i.e., sweating).
The primary objective of this study is to evaluate different forms of Pavlovian fear
extinction in patients who suffer from pathological anxiety. The investigators are interested
in the effects of extinction and extinction retention over a delay in regions that are known
to show abnormalities in anxiety populations. This includes the amygdala, ventromedial
prefrontal cortex, and the hippocampus.
The study is testing behavioral strategies and does not include any pharmacological
manipulations.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03535805 -
Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances
|
N/A | |
Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
Recruiting |
NCT05419934 -
EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial
|
N/A | |
Active, not recruiting |
NCT04136054 -
Better Sleep in Psychiatric Care - Anxiety and Affective Disorders
|
N/A | |
Completed |
NCT04091139 -
Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong
|
Phase 2/Phase 3 | |
Completed |
NCT04647318 -
Physiological Response to Self-compassion Versus Relaxation
|
N/A | |
Active, not recruiting |
NCT05114824 -
Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students
|
N/A | |
Recruiting |
NCT05843695 -
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
|
N/A | |
Completed |
NCT05078450 -
Mood Lifters Online for Graduate Students and Young Professionals
|
N/A | |
Not yet recruiting |
NCT06162624 -
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
|
N/A | |
Not yet recruiting |
NCT05747131 -
Emotion Detectives In-Out: Feasibility and Efficacy of a Blended Version of the Unified Protocol for Children
|
N/A | |
Not yet recruiting |
NCT05863637 -
Intensive Short-Term Dynamic Psychotherapy (ISTDP) for Anxiety Diagnoses in a Primary Care Setting
|
N/A | |
Not yet recruiting |
NCT05225701 -
Efficacy of a Transdiagnostic Guided Internet-Delivered Intervention for Emotional, Trauma and Stress-Related Disorders.
|
N/A | |
Completed |
NCT02579915 -
Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC)
|
N/A | |
Recruiting |
NCT02186366 -
Efficacy Study of Abdominal Massage Therapy to Treat Generalized Anxiety Disorder of Deficiency of Both Heart and Spleen Type
|
N/A | |
Recruiting |
NCT02376959 -
Effect of Spiritist "Passe" Energy Therapy in Reducing Anxiety in Volunteers
|
N/A | |
Not yet recruiting |
NCT02126787 -
Short-term, Intensive Psychodynamic Group Therapy Versus Cognitive-behavioral Group Therapy in the Day Treatment
|
N/A | |
Withdrawn |
NCT01953042 -
Benefits of a Psychoeducation Program for Those Awaiting Treatment for OCD and OCD Spectrum Disorders
|
N/A | |
Completed |
NCT02134730 -
School-based Universal Prevention for Anxiety and Depression in Sweden: A Cluster-randomized Trial
|
N/A | |
Completed |
NCT01636791 -
CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care
|
Phase 3 |