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AMD clinical trials

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NCT ID: NCT04078672 Completed - AMD Clinical Trials

Retinal Imaging Using NOTAL-OCT V3.0

Start date: December 2, 2019
Phase: N/A
Study type: Interventional

The study will include up to 250 AMD patients and up to 30 DR patients. In Tel Aviv medical center up to 100 AMD/ 20 DR patients will be recruited; In Assuta HaShalom up to 100 AMD/10 DR patients will be recruited; In Bnei Zion medical center up to 50 AMD patients will be recruited. 4.1 Study population 1. AMD patients - intermediate and advanced AMD (with active or non-active CNV) 2. DR patients - with and without edema 4.2 Inclusion criteria 1. Ability and agreement to give informed consent (IC) 2. Diagnosis of AMD or DR in SE by OCT 3. Ability to undergo OCT scans 4. VA of 20/400 (6/120) or better in study eye(s) 4.3 Exclusion criteria 1. Patient with dilated eye(s)

NCT ID: NCT03843840 Completed - Clinical trials for Diabetic Retinopathy

Dual Wavelength OCT

Start date: February 15, 2019
Phase:
Study type: Observational

The purpose of this research is the evaluation of a combined coaxial optical coherence tomography (OCT) system to image retina/choroid and to evaluate if post processing of the data can give us insights into property of the tissue imaged.

NCT ID: NCT03600519 Completed - AMD Clinical Trials

Retinal Imaging Using NOTAL-OCT V2.5

Start date: July 22, 2018
Phase:
Study type: Observational

Primary objectives: To compare between retinal measurements, done by the NOTAL-OCT V2.5 device and a commercial OCT. Secondary objectives: 1. To evaluate the level of agreement between the NOTAL-OCT V2.5 and a commercial OCT in the presence of fluid as identified in the OCT images, in the central 10 degrees of the macula. 2. To evaluate the repeatability of the NOTAL-OCT V2.5

NCT ID: NCT03372746 Completed - AMD Clinical Trials

Generation of Induced Pluripotent Stem (iPS) Cell Lines From Skin Fibroblast Cells of Participants With Age-Related Macular Degeneration

Start date: May 23, 2018
Phase:
Study type: Observational

Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Currently, there is no safe way to obtain cells from the eye to study. But researchers now can turn other types of cells, like skin or blood, into induced pluripotent stem (iPS) cells. These can be grown in a lab and turned into other types of cells, like cells from the eye. This will allow researchers to understand and treat diseases of the eye such as AMD. Objectives: To establish a bank of samples that can be changed into other cell types, such as eye cells, to better understand diseases such as AMD. Also to test drugs in order to treat various eye diseases. Eligibility: People who provided DNA samples in another protocol (07-EI-0025) Design: Participants will be screened with their data from the previous protocol. Participants with select genetic variants will be chosen and contacted via phone. Participants will have a punch skin biopsy. The skin will be washed. A numbing medication will be injected. A small piece of skin will be removed with a biopsy tool. The site will be covered with a dressing. They will receive instructions on how to care for the area. They will have follow-up visits if needed for clinical care for the area. Participants may be asked to return if their first sample did not provide enough cells for the lab. Participants sample will be developed into eye cells. The cells will be used to understand diseases and test new drugs.

NCT ID: NCT03367767 Completed - Cancer Clinical Trials

Age-Related Eye Disease Study 2 (AREDS2) 10-year Follow-On

Start date: May 23, 2018
Phase:
Study type: Observational

Background: Age-related macular degeneration (AMD) and cataracts are two eye diseases. They were studied in the Age-Related Eye Disease Study (AREDS2) and the AREDS2 Follow-On study. These studies followed the natural course of the diseases. They also provided data on the long-term effects of certain oral supplements on AMD. Objective: To study the long-term effects of oral supplements on several things. These include incidences of lung cancer, development of late AMD, cataract surgery, cognitive function, and cardiovascular events. Eligibility: Former AREDS2 and AREDS2 Follow-On participants Design: Participants will have 1 visit. It will include: An eye exam that tests how well participants can see, measures eye pressure, and checks eye movements. The pupil will be dilated with eye drops. Pictures will be taken of the retina and the inside of the eye. Participants will grip a device in their hand to measure their grip strength. A blood sample will be taken. This will be stored for future genetic research. Cells may be created from the sample. A small sample of skin will be taken. Sponsoring Institution: National Eye Institute

NCT ID: NCT03324542 Completed - AMD Clinical Trials

Real World Outcomes of Intravitreal Anti-vascular Endothelial Growth Factors for Neovascular Age Related Macular Degeneration in Taiwan

OIVAEGFFAMDIT
Start date: April 3, 2017
Phase:
Study type: Observational

Purpose To report the long-term efficacy of patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) in Changhua Christian Hospital in Taiwan. Method Retrospective case series of patients with nAMD that were treated with intravitreal injection of anti-VEGF and had a minimum follow up of 48 months. Every patient was initially treated with 3 loading doses of either bevacizumab or ranibizumab, followed by a loose treat and extend regimen. Eyes were divided into 2 groups according to whether aflibercept was later used as a rescue therapy (group 2) or not (group 1). Patients underwent best-corrected visual acuity (BCVA) testing, optical coherence tomography, and ophthalmic examination at baseline and all the scheduled follow-up visits.

NCT ID: NCT03322930 Completed - Clinical trials for Retinitis Pigmentosa

Rod Sensitivity in Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP)

Start date: October 1, 2017
Phase:
Study type: Observational

A new fundus-guided microperimeter (MP-3S) has been developed by Nidek, Inc. to track the fundus of the patient and present stimuli in specific anatomically-defined locations. Furthermore, this tracking means that exactly the same locations can be tested on subsequent (follow-up) visits. The investigators will use a method called two-color perimetry to map rod and cone sensitivity on this device. With this technique, the sensitivity difference (blue-red) to chromatic test stimuli can be used to determine whether rods, cones or both photoreceptor systems mediate the threshold at a given location in the macula.

NCT ID: NCT01915238 Completed - AMD Clinical Trials

Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study

Start date: July 16, 2013
Phase: N/A
Study type: Observational

Background: - The Age-Related Eye Disease 2 Study (AREDS2) looked at two eye diseases. These were age-related macular degeneration (AMD) and cataracts. Participants in that study took supplement pills and some participants had additional pictures taken of their eyes. That study is now over. Researchers want to do a follow-up study after participants finish taking the pills, to see if they cause long-term effects on AMD. This study will be combined with follow-up visits of the AREDS2 study if possible. Objectives: - To learn more about the effect of oral supplements on AMD. Eligibility: - People who completed the AREDS2 study. Design: - Participants will have up to 2 study visits over 6 18 months. - Each visit will last up to 5 hours. The visits will be combined with annual follow-up visits in the AREDS2 study if possible. - At each visit, participants will undergo an eye exam and photography. - The eye exam includes testing sight, measuring eye pressure, and checking eye movements. To examine the inside of the eye, the pupil will be dilated with eye drops. - Photographs of the inside of the eye may be taken during the eye exam and while the eyes are dilated. - A contact lens may be placed on the eye briefly to look at the retina at the back of the eye.

NCT ID: NCT01778491 Completed - Clinical trials for Age-Related Macular Degeneration

AMD Phenotype and Genotype Study

Start date: November 5, 2012
Phase:
Study type: Observational

Background: - Age-related macular degeneration (AMD) is a disease that blurs the sharp vision needed for activities such as reading, sewing, and driving. It affects the macula, the center of the retina at the back of the eye, which allows a person to see fine detail. Researchers want to collect medical histories, eye exam data, and genetic information that may be associated with AMD. They want to compare this information with information collected from people without AMD. Objectives: - To collect medical information and gene samples for researchers studying AMD. Eligibility: - Individuals between and 60 and 90 years of age who have AMD in at least one eye. - Individuals between and 60 and 90 years of age who have no AMD in either eye. Design: - This study will involve one study visit. This study visit will last 6 to 8 hours. - Participants will have the following tests and exams as part of their study visit: - Full physical exam and medical history - Full eye examination - Laser scan of the eye - Retina function test - Vision sensitivity test - Optional blood sample (for genetic study) - No treatment will be provided as part of this study.

NCT ID: NCT01766596 Completed - Glaucoma Clinical Trials

Study the Signs of Ocular Degeneration in a Population Cohort (Dijon 3C Montrachet Cohort)

3C
Start date: October 2009
Phase: N/A
Study type: Interventional

The aim of the study proposed in Dijon is above all to focus on the possible relationship between age-related ocular pathologies (AMD and glaucoma) and et les degenerative neurological and cardiac pathologies. The principal objective is to seek in subjects who have undergone cerebral MRI and echocardiography, associations between the thickness of postganglionic fibers measured by Optical Coherence Tomography at the 7th year (n=1500) and signs of cerebral impairment (psycho-cognitive tests, circulation time, MRI signs). This association will be studied after taking into account the principal environmental (particularly dietary) and genetic risk factors.