Nitrate Supplementation and Muscle Blood Flow

Aging Clinical Trial

Official title:

Nitric Oxide Bioavailability and Dynamics of Blood Flow and Vasodilation With Age

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03459027
• Other study ID #: 201708795
• Status: Completed
• Phase: N/A
• Start date: October 10, 2017
• Est. completion date: February 8, 2018

Study information

• Verified date: January 2019
• Source: University of Iowa
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.

Description:

Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: February 8, 2018
• Est. primary completion date: February 8, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 80 Years

Eligibility

Inclusion Criteria:

• Healthy older adults 60-80 years of age

Exclusion Criteria:

• Hypertension,

• Smoking,

• Heart disease,

• Diabetes,

• Body mass index (BMI) = 30 kg/m2,

• Autonomic disorders and other conditions that may alter blood pressure or vascular function

• Medications that might normally alter blood pressure or vascular function.

• Older women taking hormone replacement therapy medications.

Related Conditions & MeSH terms

• Active Hyperemia
• Aging
• Blood Pressure
• Hyperemia
• Vasodilation

Intervention

Dietary Supplement:
• Super Beets
Nitrate rich beetroot powder (10g) acutely
• Beetroot powder
Nitrate devoid beetroot powder (10g) acutely

Locations

Country	Name	City	State
United States	Medical Education Building	Iowa City	Iowa

Sponsors (1)

Lead Sponsor	Collaborator
University of Iowa

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Skeletal Muscle Blood Flow within the Leg via Doppler Ultrasound	Leg blood flow via Doppler ultrasound examined during dynamic knee extension exercise. Change in blood flow in response to dynamic knee exercise will be measured to examine the influence of dietary nitrate.	Pre and 2 hours post acute ingestion of dietary nitrate and placebo with at least 5 days of separation between visits.