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NCT05295576 Clinical Trial

Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients

Aggressive Periodontitis Clinical Trial

Official title:
Effect of Non Surgical Periodontal Therapy on Levels of Il-17 and Il-18 in Chronic Periodontitis Patients Versus Periodontally Healthy Individuals

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05295576
Other study ID # FUE12
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 27, 2021
Est. completion date December 30, 2021

Study information
Verified date March 2022
Source Future University in Egypt
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

Description:

Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls. Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).

Recruitment information / eligibility
Status Completed
Enrollment 50
Est. completion date December 30, 2021
Est. primary completion date December 15, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 30 Years to 60 Years
Eligibility Inclusion Criteria: - Medically free subjects . - both genders . - age range between 30 to 60 years old . Exclusion Criteria: - Subjects with periodontal surgeries in the last 6 months. - Subjects with prior use of antibiotics in the last 6 months. - Smokers. - Pregnant and lactating females were excluded. - Lactating females.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• non surgical periodontal therapy
Scaling and root planing

Locations
Country Name City State
Egypt Future university in Egypt Cairo

Sponsors (1)
Lead Sponsor Collaborator
Future University in Egypt

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary measure levels of Il-17 and Il-18 in chronic periodontitis patients measure levels of Il-17 and Il-18 in GCF of chronic periodontitis patients Change from Baseline Il-17 andIl-18 at 3 months
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