The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

Aggressive Periodontitis Clinical Trial

Official title:

The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis Patients: A Randomized Controlled Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05043935
• Other study ID #: waiting
• Status: Recruiting
• Phase: N/A
• Start date: November 22, 2021
• Est. completion date: October 2024

Study information

• Verified date: April 2024
• Source: Kafrelsheikh University
• Contact: Dalia R Issa, PhD
• Phone: 01007753636
• Email: dalia_rasheed[@]hotmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: October 2024
• Est. primary completion date: September 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• systemically healthy

• non- smoker,

• not received any periodontal treatment within the last 6 months,

• no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months

Exclusion Criteria:

• any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment,

• any medical condition that required antibiotic prophylaxis before the treatment,

• smoking,

• pregnancy and lactation,

• ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period,

• any physical limitations or restrictions that might preclude normal oral hygiene procedures.

Related Conditions & MeSH terms

• Aggression
• Aggressive Periodontitis
• L-PRF
• Periodontitis
• Photodynamic Therapy

Intervention

Procedure:
• L-PRF with antimicrobial photodynamic therapy
Application of L-PRF with antimicrobial photodynamic therapy in the defect
• antimicrobial photodynamic therapy without L-PRF
application of antimicrobial photodynamic therapy without L-PRF in the defect

Locations

Country	Name	City	State
Egypt	Faculty of Dentistry, Kafrelsheikh University	Kafr Ash Shaykh

Sponsors (1)

Lead Sponsor	Collaborator
Kafrelsheikh University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical evaluation and measurements of the defect in millimeters	Changes in clinical measurements in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF	9 months
Primary	Radiographic evaluation and measurements of the defect in millimeters	Changes in bone formation in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF	9 months