Aggressive Periodontitis Clinical Trial
Official title:
Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study
Verified date | October 2018 |
Source | Mohammed V Souissi University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of the study was to compare the clinical effects of systemic use of doxycycline to amoxicillin plus metronidazole as adjunctive treatment in nonsurgical debridement of aggressive periodontitis (AgP). Twenty four patients with aggressive periodontitis were enrolled in this clinical study. They all received oral hygiene instruction and full-mouth nonsurgical debridement using manual instruments. The test group received as adjunctive antibiotic treatment 200 mg of doxycycline the first day followed by 100 mg per day during 14 days. The control group received 500 of amoxicillin and 250 of metronidazole, three times a day for 7 days.
Status | Completed |
Enrollment | 24 |
Est. completion date | December 8, 2014 |
Est. primary completion date | June 6, 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 16 Years to 36 Years |
Eligibility |
Inclusion Criteria: - subjects in good general health, - presence of at least 20 teeth, - no periodontal treatment performed during the previous 12 months, - absence of antibiotic intake during six months before the study, - and no known allergies to antibiotics used in the study Exclusion Criteria: - pregnancy, - lactation, - and smoking. |
Country | Name | City | State |
---|---|---|---|
Morocco | BENRACHADI Latifa | Rabat |
Lead Sponsor | Collaborator |
---|---|
Mohammed V Souissi University |
Morocco,
Guerrero A, Nibali L, Lambertenghi R, Ready D, Suvan J, Griffiths GS, Wilson M, Tonetti MS. Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial. J Clin Periodontol. 2014 Nov;41(11):1080-9. doi: 10.1111/jcpe.12299. Epub 2014 Sep 11. — View Citation
Herrera D, Sanz M, Jepsen S, Needleman I, Roldán S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol. 2002;29 Suppl 3:136-59; discussion 160-2. Review. — View Citation
Xajigeorgiou C, Sakellari D, Slini T, Baka A, Konstantinidis A. Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. J Clin Periodontol. 2006 Apr;33(4):254-64. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Decrease of periodontal pockets = 4mm | • Probing pockets depths were assessed to the nearest millimeter using a standard periodontal probe, when recruiting patient at baseline and the re-evaluation 3 months after nonsurgical mechanical debridement. | 3 months | |
Secondary | Plaque index decrease | Plaque index was assessed by using Loe and silness scores at baseline and the re-evaluation 3 months after nonsurgical mechanical debridement | 3 months | |
Secondary | Gingival index decrease | Gingival index was assessed by using Loe and silness scores at baseline and and at the re-evaluation 3 months after nonsurgical mechanical debridement | 3 months |
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