Aggressive Periodontitis Clinical Trial
Official title:
Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial
Verified date | October 2017 |
Source | Universidade Estadual Paulista Júlio de Mesquita Filho |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.
Status | Completed |
Enrollment | 40 |
Est. completion date | November 2015 |
Est. primary completion date | August 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - diagnosis of Generalized Aggressive Periodontitis - presence of =20 teeth - presence of = 6 sites presenting probing depth (PD) =5mm with bleeding on probing (BOP) and =2 sites with PD =7mm (including incisors and first molars, in addition to two other non-contiguous teeth between them) - good general health - <35 years of age - agree to participate in the study and sign a written consent Exclusion Criteria: - pregnant or lactating - suffering from any other systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease - received antimicrobials in the previous 6 months - taking long-term anti-inflammatory drugs - received a course of periodontal treatment within the last 12 months - smoked |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Universidade Estadual Paulista Júlio de Mesquita Filho | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. |
Casarin RC, Peloso Ribeiro ED, Sallum EA, Nociti FH Jr, Gonçalves RB, Casati MZ. The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis trea — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical Attachment Level | Distance from bottom of pocket to the cement-enamel junction (CEJ). | 6 months | |
Secondary | Probing Depth | Distance from the bottom of sulcus/pocket to gingival margin | 6 months |
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